1629161-89-2Relevant articles and documents
Palladium-catalyzed carbonylative coupling of α-chloroketones with hydrazines: a simple route to pyrazolone derivatives
Capua, Martina,Granito, Catia,Perrone, Serena,Salomone, Antonio,Troisi, Luigino
, p. 3363 - 3367 (2016)
A range of pyrazol-5-one and pyrazol-3-one derivatives has been synthesized in a single step via a palladium-catalyzed carbonylation of aromatic or aliphatic α-chloroketones, in the presence of aromatic or aliphatic hydrazines. A reaction mechanism, explaining the observed regioselectivity, has been also discussed.
Asymmetric synthesis of spiropyrazolones through phosphine-catalyzed [4+1] annulation
Han, Xiaoyu,Yao, Weijun,Wang, Tianli,Tan, Yong Ren,Yan, Ziyu,Kwiatkowski, Jacek,Lu, Yixin
supporting information, p. 5643 - 5647 (2014/06/10)
An enantioselective synthesis of spiropyrazolones from allenoate-derived MBH acetates and pyrazolones through a phosphine-mediated [4+1] annulation process has been developed. Spiropyrazolones were readily prepared in good chemical yields and good to high enantioselectivities. This is the first asymmetric example in which α-substituted allenoates were utilized as a C4 synthon for phosphine-catalyzed [4+1] annulation. Optically enriched 4-spiro-5-pyrazolones were prepared through phosphine-catalyzed enantioselective [4+1] annulation. In this study, substituted pyrazolones were used as a C1 synthon in cycloaddition for the first time. Moreover, this is the first report in which α-substituted allenoates were utilized in an asymmetric [4+1] annulation.
