162922-18-1

Basic information

• Product Name: [2-(TRIFLUOROMETHYL)PHENOXY]ACETIC ACID
• Synonyms: [2-(TRIFLUOROMETHYL)PHENOXY]ACETIC ACID;BUTTPARK 80\07-12
• CAS NO: 162922-18-1
• Molecular Formula: C₉H₇F₃O₃
• Molecular Weight: 220.15
• Mol File: 162922-18-1.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 295.9±40.0 °C(Predicted)
• Appearance: /
• Density: 1.392±0.06 g/cm3(Predicted)
• PKA: 3.00±0.10(Predicted)
• CAS DataBase Reference: [2-(TRIFLUOROMETHYL)PHENOXY]ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: [2-(TRIFLUOROMETHYL)PHENOXY]ACETIC ACID(162922-18-1)
• EPA Substance Registry System: [2-(TRIFLUOROMETHYL)PHENOXY]ACETIC ACID(162922-18-1)

Safety Data

• Hazardous Substances Data: 162922-18-1(Hazardous Substances Data)

Usage

General Description

[2-(Trifluoromethyl)phenoxy]acetic acid is a chemical compound with the molecular formula C9H7F3O3. It is a chiral selective herbicide commonly used in agriculture to control the growth of broadleaf weeds in various food and feed crops. [2-(TRIFLUOROMETHYL)PHENOXY]ACETIC ACID works by inhibiting the enzyme acetolactate synthase, which is essential for the biosynthesis of the branched-chain amino acids valine, leucine, and isoleucine in plants. The inhibition of this enzyme ultimately leads to the death of the targeted weeds. Although it is effective as an herbicide, [2-(Trifluoromethyl)phenoxy]acetic acid has been the subject of environmental and health concerns due to its persistent nature in soil and water, potential toxicity to non-target organisms, and potential risk of bioaccumulation in the environment.

Upstream product

• 444-30-4 2-(trifluoromethyl)phenol 
• 105-36-2 ethyl bromoacetate 
• 476155-15-4 ethyl 2-(2-(trifluoromethyl)phenoxy)acetate 
• 79-08-3 bromoacetic acid 

Downstream Products

• 1086061-32-6 1'-{2-(2-trifluoromethylphenoxy)acetyl}spiro(indole-3,4'-piperidine)-2(1H)-one 
• 1086062-98-7 1-methyl-1'-{2-(2-trifluoromethylphenoxy)acetyl}spiro(indole-3,4'-piperidine)-2-one 
• 1086063-09-3 1-cyclopropyl-1'-{2-(2-trifluoromethylphenoxy)acetyl}spiro(indole-3,4'-piperidine)-2-one 
• 1204429-71-9 1-[spiro(indene-1,4'-piperidine)-1'-yl]-2-[2-(trifluoromethyl)phenoxy]ethanone 

Relevant articles and documents

Discovery, synthesis and biological characterization of a series of: N -(1-(1,1-dioxidotetrahydrothiophen-3-yl)-3-methyl-1 H -pyrazol-5-yl)acetamide ethers as novel GIRK1/2 potassium channel activators

The present study describes the discovery and characterization of a series of N-(1-(1,1-dioxidotetrahydrothiophen-3-yl)-3-methyl-1H-pyrazol-5-yl)acetamide ethers as G protein-gated inwardly-rectifying potassium (GIRK) channel activators. From our previous lead optimization efforts, we have identified a new ether-based scaffold and paired this with a novel sulfone-based head group to identify a potent and selective GIRK1/2 activator. In addition, we evaluated the compounds in tier 1 DMPK assays and have identified compounds that display nanomolar potency as GIRK1/2 activators with improved metabolic stability over the prototypical urea-based compounds. This journal is

1,2-DIAZETIDIN-3-ONE DERIVATIVES AND DRUGS CONTAINING SAME

It is to provide a novel compound useful for preventing and/or treating diseases that involves 11 beta-hydroxysteroid dehydrogenase 1 (in particular diabetes, insulin resistance, diabetes complication, obesity, dyslipidemia, hypertension, fattyliver, or metabolic syndrome). A 1,2-diazetidin-3-one derivative represented by the following general formula (1) or salt thereof, or their solvate

CHEMICAL COMPOUNDS

This invention relates to non-steroidal compounds that are modulators of androgen receptor, and also to the methods for the making and use of such compounds.