162940-59-2

Upstream product

• 1821-12-1 4-Phenylbutyric acid 
• 2046-17-5 methyl 3-(benzyl)propanoate 
• 162939-97-1 4-(4-acetylbenzene)butanoic acid methyl ester 

Downstream Products

• 162941-09-5 4-[4-(1-Chloro-ethyl)-phenyl]-butyric acid methyl ester 
• 162938-58-1 methyl 4-[4-[1-(4-chlorophenylsulfonylamino)ethyl]phenyl]butyrate 
• 162977-09-5 4-[4-(1-Azido-ethyl)-phenyl]-butyric acid methyl ester 
• 162941-64-2 4-[4-(1-Amino-ethyl)-phenyl]-butyric acid methyl ester 
• 438633-78-4 4-(4-ethenylbenzene)butanoic acid methyl ester 

Relevant academic research and scientific papers

Soluble polystyrenes functionalized by triorgano[(1-oxoalkyl)oxy]stannanes (=triorganotin carboxylates): Synthesis, structure, and anion-recognition characteristics

Polystyrene copolymers of the type (P-H)1-x(P-(CH2)n- COOSnR3)x containing [(1-oxoalkyl)oxy]triphenylstannane or tributyl[(1-oxoalkyl)oxy]stannanes as side chains (P-H=styrene; P-(CH2)n-COOSnR3 =para-substituted styrene-like monomeric unit with R=Ph (x=0.1), Bu (x=0.5); n=2-4) were investigated. The tributyl[(1-oxoalkyl)oxy]stannane copolymer was prepared by direct conversion of the corresponding copolymeric methyl esters with hexabutyldistannoxane. By contrast, the [(1-oxoalkyl)oxy]triphenylstannane copolymer could be prepared only by a procedure involving two reaction steps consisting of a preliminary hydrolysis of the related methyl ester (P-H)1-x(P-CH2)n-COOMe)x followed by functionalization of the corresponding poly(carboxylic acid) (P-H)1-x(P-(CH2n-COOH)x with hydroxytriphenylstannane. Attempts to directly convert the methyl ester with hydroxytriphenylstannane led to the formation of uncompletely functionalized product. The structure of the stannane-functionalized polymers was investigated in solution and solid state by NMR, IR, and thermal analysis. The tributylstannane and triphenylstannane copolymers were assessed as chloride-selective anion carriers in polymeric-liquid-membrane potentiometric ion-selective electrodes.

Synthesis and dual antagonistic activity against thromboxane A2 and leukotriene D4 of [4-[1-(benzenesulfonamido)alkyl]phenyl]alkanoic acid derivatives

In order to find new antiasthmatic agents with dual antagonistic activity against thromboxane A2 (TXA2) and leukotriene D4 (LTD4) receptors, synthesis and pharmacological evaluation of various [4-[1- (benzenesulfonamido)-alkyl]phenyl]alkanoic acid derivatives were undertaken. TXA2 and LTD4 antagonistic activities in vitro were evaluated by measuring the inhibitory effects on U-46619-induced contraction of guinea-pig trachea and LTD4-induced contraction of guinea-pig ileum and trachea. Several compounds showed satisfactory dual antagonistic activities, and their effect (after oral administration) on LTD4-induced bronchoconstriction in guinea- pig in vivo was examined. The results demonstrated that both 4-[4-[1-(4- chlorobenzenesulfonamido)hexyl]phenyl]butyric acid (12e) and 4-[4[1-(4- chlorobenzenesulfonamido)-5-methylhexyl]phenyl]butyric acid (12m) possessed good anti-LTD, activities. Compounds 12e and 12m were then evaluated for other related pharmacological effects involving the arachidonic acid cascade. These compounds appear to be hybrid eicosanoids antagonists having antagonistic activity against contraction of guinea-pig trachea induced by prostaglandin D2 (PGD2) and PGF(2α), as well as TXA2 and LTD4 antagonistic activities.

Synthesis and thoromboxane A2 antagonistic activity of [[1-aryl(or benzyl)-1-(benzenesulfonamido)methyl]phenyl]alkanoic acid derivatives

In order to find a new antiasthmatic and antithrombotic agents, various [[1-aryl(or benzyl)-1-(benzenesulfonamido)methyl]phenyl]alkanoic acid derivatives were synthesized. Evaluation of these compounds for thromboxane A2 (TXA2) antag