16297-14-6

Basic information

• Product Name: 2 3 5 6-TETRAFLUORO-4-METHYLPYRIDINE 9&
• Synonyms: 2 3 5 6-TETRAFLUORO-4-METHYLPYRIDINE 9&;2,3,5,6-tetrafluoro-4-methylpyridine;4-Methyl-2,3,5,6-tetrafluoropyridine 99%+;Pyridine,2,3,5,6-tetrafluoro-4-methyl-
• CAS NO: 16297-14-6
• Molecular Formula: C₆H₃F₄N
• Molecular Weight: 165.0883328
• EINECS: 216-629-0
• Mol File: 16297-14-6.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 130-131 °C(lit.)
• Flash Point: 89 °F
• Appearance: /
• Density: 1.44 g/mL at 25 °C(lit.)
• Vapor Pressure: 5880mmHg at 25°C
• Refractive Index: n20/D 1.414(lit.)
• PKA: -10.29±0.28(Predicted)
• CAS DataBase Reference: 2 3 5 6-TETRAFLUORO-4-METHYLPYRIDINE 9&(CAS DataBase Reference)
• NIST Chemistry Reference: 2 3 5 6-TETRAFLUORO-4-METHYLPYRIDINE 9&(16297-14-6)
• EPA Substance Registry System: 2 3 5 6-TETRAFLUORO-4-METHYLPYRIDINE 9&(16297-14-6)

Safety Data

• Hazard Codes: Xi,F
• Statements: 10-36/37/38
• Safety Statements: 16-26-36/37/39
• RIDADR: UN 1993 3/PG 3
• WGK Germany: 3
• HazardClass: 3.2
• PackingGroup: III
• Hazardous Substances Data: 16297-14-6(Hazardous Substances Data)

Usage

General Description

2 3 5 6-Tetrafluoro-4-methylpyridine is a chemical compound with the molecular formula C6H4F4N. It is a pyridine derivative and is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. The compound is a colorless liquid with a boiling point of 156-157°C and a flash point of 57°C. It is also known for its strong odor and is considered to be a volatile organic compound. 2 3 5 6-Tetrafluoro-4-methylpyridine is primarily used in the production of various derivatives and specialty chemicals, and has applications in the pharmaceutical and agricultural industries. It is important to handle this chemical with care and follow safety protocols due to its potential hazards.

InChI:InChI=1/C2H2F2/c3-1-2-4/h1-2H/b2-1+

Upstream product

• 714-37-4 nonafluoro-2,3,4,5-tetrahydropyridine 
• 2375-90-8 4-methoxy-2,3,5,6-tetrafluoropyridine 
• 836-77-1 perfluoro-N-fluoropiperidine 
• 110-86-1 pyridine 
• 700-16-3 Pentafluoropyridine 
• 917-54-4 methyllithium 
• 75-16-1 methylmagnesium bromide 
• 16297-07-7 2,3,5,6-tetrafluoro-4-pyridinecarbonitrile 

Downstream Products

• 16857-78-6 2-amino-3,5,6-trifluoro-4-methylpyridine 
• 74718-94-8 2,6-diamino-3,5-difluoro-4-methylpyridine 
• 183307-67-7 3-[(3,5-difluoro-4-methyl-6-phenoxypyridin-2-yl)oxy]benzonitrile 
• 183306-87-8 3-[(3,5,6-trifluoro-4-methylpyridin-2-yl)oxy]benzonitrile 
• 219546-71-1 4-methyl-2.3.5-trifluoro-6-(3-trifluoromethylphenoxy)pyridine 
• 183307-05-3 3-[(3,5,6-trifluoro-4-methylpyridin-2-yl)oxy]-4-methoxybenzonitrile 

Relevant articles and documents

Synthesis of some fluorine-containing pyridinealdoximes of potential use for the treatment of organophosphorus nerve-agent poisoning

Fluoroheterocyclic aldoximes were screened as therapeutic agents for the treatment of anticholinesterase poisoning. 2-Fluoropyridine-3- and -6-aldoxime, and 3-fluoropyridine-2- and -4-aldoxime, were synthesised. Attempts to obtain 3,5,6-trifluoropyridine-2,4-bis(aldoxime) and -2-aldoxime, however, proved unsuccessful. Pentafluorobenzaldoxime was prepared by oximation of pentafluorobenzaldehyde. Acid dissociation constants (pKa) and second-order rate constants (kox-) of the fluorinated pyridinealdoximes towards sarin were measured. 2,3,5,6-Tetrafluoropyridine-4- aldoxime had the best profile: its kox- approached that of the therapeutic oxime P2S (310 vs. 120 l mol-1 min-1), but its higher pKa (9.1 vs. 7.8) fell short of the target figure of 8 required for reactivation of inhibited acetylcholinesterase in vivo. N-alkylation of the fluorinated pyridine-aldoximes may reduce their pK a nearer to 8 and enhance their therapeutic potential. Crown Copyright