162970-49-2

Basic information

• Product Name: 2-Pyrrolidinone,3,3-difluoro-(9CI)
• Synonyms: 2-Pyrrolidinone,3,3-difluoro-(9CI);3,3-difluoro-2-Pyrrolidinone;3,3-difluoropyrrolidin-2-one
• CAS NO: 162970-49-2
• Molecular Formula: C4H5F2NO
• Molecular Weight: 121.086
• Product Categories: PYRROLIDINE
• Mol File: 162970-49-2.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Pyrrolidinone,3,3-difluoro-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyrrolidinone,3,3-difluoro-(9CI)(162970-49-2)
• EPA Substance Registry System: 2-Pyrrolidinone,3,3-difluoro-(9CI)(162970-49-2)

Safety Data

• Hazardous Substances Data: 162970-49-2(Hazardous Substances Data)

Usage

General Description

2-Pyrrolidinone,3,3-difluoro-(9CI) is a chemical compound with the molecular formula C4H6F2NO. It is a colorless liquid with a faint odor, used primarily as a solvent in various industrial applications including pharmaceuticals, polymer processing, and electronics manufacturing. 2-Pyrrolidinone,3,3-difluoro-(9CI) is known for its high solvency power and low toxicity, making it a versatile option for dissolving a wide range of substances. However, caution should be exercised when handling this chemical as it can be irritating to the skin and eyes, and prolonged exposure may lead to adverse health effects. Additionally, it is important to follow proper safety precautions and regulations when using 2-Pyrrolidinone,3,3-difluoro-(9CI) to minimize the risk of accidents or environmental damage.

Upstream product

• 1361968-69-5 N,N-diethyl-2,2-difluoro-4-nitrobutanamide 
• 162970-44-7 methyl 4-azido-2,2-difluorobutanoate 

Downstream Products

• 163457-23-6 3,3-difluoropyrrolidine hydrochloride 

Relevant articles and documents

Carbazole-containing amides and ureas: Discovery of cryptochrome modulators as antihyperglycemic agents

A series of novel carbazole-containing amides and ureas were synthesized. A structure–activity relationship study of these compounds led to the identification of potent cryptochrome modulators. Based on the desired pharmacokinetic/pharmacodynamic parameters and the results of efficacy studies in db/db mice, compound 50 was selected for further profiling.

An efficient synthesis of 3,3-difluoro-pyrrolidine hydrochloride starting with 2-chloro-2,2-difluoroacetic acid

A facile and fluorination-free synthesis of 3,3-difluoropyrrolidine hydrochloride (3), an important synthon in the synthesis of biologically active compounds, is reported. The seven-step synthesis starts from the commercially available 2-chloro-2,2-difluoroacetic acid (1) in a three-step telescoped process that produces crystalline N,N-diethyl-2,2-difluoro-3-hydroxy-4- nitrobutanamide (2). A convenient and high-yielding reductive nitromethylation of 2 followed by a catalytic hydrogenation/cyclization sequence and borane reduction affords 3 in good yield and purity.