162970-49-2

Usage

Uses

Used in Pharmaceutical Industry:
2-Pyrrolidinone,3,3-difluoro-(9CI) is used as a solvent for dissolving active pharmaceutical ingredients and other components in the manufacturing of medications. Its high solvency power allows for the efficient production of pharmaceutical formulations.
Used in Polymer Processing:
In the polymer industry, 2-Pyrrolidinone,3,3-difluoro-(9CI) serves as a solvent for dissolving polymers and additives during the production process. This helps in achieving desired properties and characteristics in the final polymer products.
Used in Electronics Manufacturing:
2-Pyrrolidinone,3,3-difluoro-(9CI) is utilized as a solvent in the electronics manufacturing industry for cleaning and degreasing electronic components, as well as for dissolving materials in the production of certain electronic devices.
Precautions:
While handling 2-Pyrrolidinone,3,3-difluoro-(9CI), it is important to exercise caution due to its potential to cause irritation to the skin and eyes. Prolonged exposure may also lead to adverse health effects. Therefore, proper safety precautions and adherence to regulations should be followed to minimize the risk of accidents or environmental damage.

Upstream product

• 1361968-69-5 N,N-diethyl-2,2-difluoro-4-nitrobutanamide 
• 162970-44-7 methyl 4-azido-2,2-difluorobutanoate 

Downstream Products

• 163457-23-6 3,3-difluoropyrrolidine hydrochloride 

Relevant academic research and scientific papers

Carbazole-containing amides and ureas: Discovery of cryptochrome modulators as antihyperglycemic agents

A series of novel carbazole-containing amides and ureas were synthesized. A structure–activity relationship study of these compounds led to the identification of potent cryptochrome modulators. Based on the desired pharmacokinetic/pharmacodynamic parameters and the results of efficacy studies in db/db mice, compound 50 was selected for further profiling.

CARBAZOLE-CONTAINING AMIDES, CARBAMATES, AND UREAS AS CRYPTOCHROME MODULATORS

The subject matter herein is directed to carbazole-containing amide, carbamate, and urea derivatives and pharmaceutically acceptable salts or hydrates thereof of structural formula I wherein the variable R1, R2, R3, R4, R5, R6, R7, A, D, E, G, J, L, M, Q, a, and b are accordingly described. Also provided are pharmaceutical compositions containing the compounds of formula I to treat a Cry-mediated disease or disorder, such as diabetes, complications associated with diabetes, Cushing's syndrome, NASH, NAFLD, asthma, and COPD.

An efficient synthesis of 3,3-difluoro-pyrrolidine hydrochloride starting with 2-chloro-2,2-difluoroacetic acid

A facile and fluorination-free synthesis of 3,3-difluoropyrrolidine hydrochloride (3), an important synthon in the synthesis of biologically active compounds, is reported. The seven-step synthesis starts from the commercially available 2-chloro-2,2-difluoroacetic acid (1) in a three-step telescoped process that produces crystalline N,N-diethyl-2,2-difluoro-3-hydroxy-4- nitrobutanamide (2). A convenient and high-yielding reductive nitromethylation of 2 followed by a catalytic hydrogenation/cyclization sequence and borane reduction affords 3 in good yield and purity.

A facile preparation method for α,α-difluoroalkanecarboxylic acids and esters. A formal difluoromethylene insertion to alkanecarboxylic acids using radical reaction

Various alkyl radicals generated by the photoreaction of a series of Barton esters reacted with 1,1-dichloro-2,2-difluoroethene to give radical adducts as the major product accompanied with self-trapping products. Primary, secondary, tertiary, benzyl, and some unsaturated alkyl radicals as well as those with another functional group such as ether, carbonyl, and azide were applicable. Barton esters of diacids also afford 1:2 adducts with a small amount of 1:1 adducts and bis-self-trapping products except for the succinic case. These adducts were hydrolyzed with AgNO3/H2O-THF to α,α-difluoroalkanecarboxylic acids and methanolyzed with AgNO3/MeOH to the corresponding methyl esters. 4-Azido-2,2-difluorobutylic acid and the methyl ester were converted to difluoro-GABA and difluoro-γ-lactams.