162971-56-4

Usage

Family

Alcohols

Specific enantiomer

(R)-4-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1-pentanol

Usage

Reagent in organic synthesis, chiral auxiliary in asymmetric synthesis

Stereochemistry importance

Impact on biological activity and pharmacokinetic properties

Potential applications

Pharmaceutical industry, development of new drugs, materials science, synthesis of advanced materials with specific properties.

Upstream product

• 126680-65-7 5-((tert-butyldimethylsilyl)oxy)pentan-2-ol 
• 626-95-9 1,4-Pentanediol 
• 1353998-64-7 C₁₃H₂₈O₃Si 
• 1353998-65-8 C₂₇H₄₄O₂Si₂ 
• 1392409-20-9 (R)-5-[[dimethyl(1,1-dimethylethyl)-silyl]oxy]-2-pentanol 
• 104784-02-3 (R)-1-<(triphenylmethyl)oxy>pentan-4-ol 
• 56718-04-8 (4R)-pentane-1,4-diol 
• 167468-64-6 (2R)-2-(tert-butyldiphenylsiloxy)propanal 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 854612-89-8 ethyl (2E,4R)-4-(t-butyldiphenylsilyloxy)-2-pentenoate 
• 561038-05-9 (R)-2-(tert-butyldiphenylsilanyloxy)propionic acid methyl ester 
• 854613-06-2 ethyl (4R)-4-(t-butyldiphenylsilyloxy)pentanoate 
• 189163-28-8 tert-Butyl-((R)-1-methyl-4-trityloxy-butoxy)-diphenyl-silane 

Downstream Products

• 1307273-43-3 (R)-4-tert-butyldiphenylsilyloxypentanal 
• 1353998-66-9 (3RS,6R)-6-tert-butyldiphenylsilyloxyhept-1-en-3-ol 
• 1353998-67-0 C₂₃H₃₀O₂Si 
• 1353998-69-2 C₂₆H₃₈O₃Si 
• 1353998-68-1 (3R,6R)-6-tert-butyldiphenylsilyloxyhept-1-en-3-ol 
• 1025896-96-1 tert-Butyl-((E)-(1R,9R)-9-methoxy-1-methyl-11-trityloxy-undec-5-enyloxy)-diphenyl-silane 
• 1026040-95-8 tert-Butyl-((E)-(1R,9S)-9-methoxy-1-methyl-11-trityloxy-undec-5-enyloxy)-diphenyl-silane 
• 189163-20-0 C₃₅H₅₆O₃Si₂ 
• 189163-19-7 (E)-(3R,11R)-11-(tert-Butyl-diphenyl-silanyloxy)-3-methoxy-dodec-6-enal 
• 189164-14-5 (E)-(3S,11R)-11-(tert-Butyl-diphenyl-silanyloxy)-3-methoxy-dodec-6-enal 
• 189163-33-5 (E)-(2R,10R)-10-Methoxy-12-trityloxy-dodec-6-en-2-ol 
• 189163-35-7 (E)-(3R,11R)-11-(tert-Butyl-diphenyl-silanyloxy)-3-methoxy-dodec-6-en-1-ol 
• 189164-15-6 (E)-(3S,11R)-11-(tert-Butyl-diphenyl-silanyloxy)-3-methoxy-dodec-6-en-1-ol 
• 189163-42-6 (2E,4E,10E)-(7S,15R)-15-(tert-Butyl-diphenyl-silanyloxy)-7-methoxy-2-methyl-hexadeca-2,4,10-trienoic acid benzyl ester 

Relevant academic research and scientific papers

Chemoenzymatic total synthesis of stagonolide-E

Asymmetric total synthesis of small ring macrolide stagonolide-E has been described in this communication. The main highlight of our synthetic strategy is the application of ME-DKR (metal enzyme combo dynamic kinetic resolution) reaction, asymmetric reduc

Total synthesis of (+)-tubelactomicin A. 2. Synthesis of the upper-half segment and completion of the total synthesis

(Chemical Equation Presented) We have completed the total synthesis of natural (+)-tubelactomicin A (1), a 16-membered macrolide antibiotic. This Letter presents a highly efficient synthesis of the upper-half segment (C14-C24) and the completion of the to

Total synthesis of dolatrienoic acid: A subunit of dolastatin 14

The (7R,15R)- and (7S,15R)-diastereomers of dolatrienoic acid were synthesized using a convergent strategy. Fragment C5-C9 was obtained through enantiodifferentiation of racemic pentane-1,3,5-triol as the key step, fixing the chirality at C7 of fragments 4 and ent-4. The chirality at C15 of the fragment C10-C16 was introduced from L-glutamic acid. Coupling of these two fragments led to the aldehydes (7R,15R)- and (7S,15R)-2 which were homologated by Horner-Wadsworth-Emmons condensation to give (7R,15R)- and (7S,15R)-dolatrienoic acids.

Asymmetric synthesis of (-)-)2E,4R,5S,11R)-cladospolide A, induced by chiral sulfoxides

An enantioselective synthesis of (-)-cladospolide in which all the chiral centers are created by asymmetric reduction of β-ketosulfoxides, is reported.