1629962-29-3Relevant academic research and scientific papers
(E)-1-BROMO-2-IODOENAMIDE DERIVATIVE OR SALT THEREOF, AND METHOD FOR PRODUCING (E)-1-BROMO-2-IODOENAMIDE DERIVATIVE OR SALT THEREOF
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, (2017/09/26)
PROBLEM TO BE SOLVED: To provide a bromo-iodoenamide obtained by controlling position and stereoselectivity. SOLUTION: Provided is a (E)-1-bromo-2-iodoenamide derivative represented by the following chemical formula (I) or a salt thereof. (In the formula, A is an aromatic hydrocarbon group or a cyclic aliphatic hydrocarbon group, where the aromatic hydrocarbon group or the cyclic aliphatic hydrocarbon group may or may not have a substituent, where the substituent, when present in a plurality, may be the same or different; B and D, together with a nitrogen atom neighboring B and D, form a ring; or B is an electron withdrawing group, and D is a hydrogen atom or an aromatic hydrocarbon group or a cyclic aliphatic hydrocarbon group which may or may not have a substituent, where the substituent, when present in a plurality, may be the same or different.) COPYRIGHT: (C)2015,JPOandINPIT
Regio-, and stereoselective iodobromination of ynamides for synthesis of (E)-1-bromo-2-iodoenamides
Ide, Masataka,Yauchi, Yuta,Iwasawa, Tetsuo
, p. 3262 - 3267 (2014/06/09)
One-step synthesis of vicinal bromoiodoenamides from ynamides through IBr addition is described. Two types of IBr were used: commercially available IBr, and in situ generated IBr. This simple protocol enables highly efficient regio- and stereoselective iodobromination of the triple bond on a gram scale in anti-mode, and provides a potentially diverse scaffold for preparation of tetrasubstituted olefins. Copyright
