1630-35-9Relevant academic research and scientific papers
A novel type of N-formylation and related reactions of amines via cyanides and esters as formylating agents
Bao, Kai,Zhang, Weige,Bu, Xiujuan,Song, Zhichun,Zhang, Liang,Cheng, Maosheng
body text, p. 5429 - 5431 (2009/03/11)
A novel N-formylation and related reactions proceed from cyanides promoted by esters. The Royal Society of Chemistry.
A PROCESS FOR THE PREPARATION OF R-(-)-N, α-DIMETHYLPHENETHYLAMINE (LEVMETAMFETAMINE) OR S-(+)-N, α-DIMETHYLPHENETHYLAMINE (METHAMPHETAMINE) FROM d-EPHEDRINE OR L-EPHEDRINE RESPECTIVELY
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Page/Page column 16, (2008/06/13)
A process for synthesis of R-(-)-N, α -Dimethylphenethylamine (Levmetamfetamine, formula I), or S-(+)-N, α - Dimethyl phenethylamine (Methamphetamine, formula II ), from d-ephedrine of formula III or l-ephedrine formula IV, the process comprising the steps of (a) acylating the d- or l-ephedrine base of formula III or formula IV with an acylating agent to make a reaction mixture containing a N- acylated ephedrines of formula V or formula VI ; (b) deoxygenation of N-acylated ephedrines to make the compound of the formula VII or Formula VIII by using Raney Nickel catalyst ; and (c) acid hydrolysis of the above deoxygenated products to get the levmetamfetamine or methamphetamine.
Reactions of (-)-Ephedrine, (+)-Norpseudoephedrine and Derivatives with N,N-Dimethylacetamid-dimethylacetal and N,N-Dimethylformamid-dimethylacetal
Koehl, M,Spreitzer, H.,Fleischhacker, W.
, p. 911 - 918 (2007/10/02)
The reactivity of (-)-ephedrine (2) and (+)-norpseudoephedrine (3) towards the amid-acetals 1 a/b has been studied.Both 2 and 3 were acetylated resp. formylated at first at the amino group.Nevertheless, derivatives of 2 and 3 possessing a trisubstituted amino group react with 1 a in a sigmatropic rearrangement to ortho substituted dimethylcarbamoylmethyl derivatives.By subsequent reduction with lithiumaluminiumhydride the aromatic compounds 8, 13, and 18 with two aminoethyl groups are easily available.In contrast to these results 1 b did not furnish any rearrangement products. Keywords. (-)-Ephedrine; (+)-Norpseudoephedrine; N,N-Dimethylacetamid-dimethylacetal; N,N-Dimethylformamid-dimethylacetal; Sympathomimetic effects; Sigmatropic rearrangements.
Rapid and Selective Formylation With Pentafluorophenyl Formate
Kisfaludy, Lajos,Oetvoes, Laszlo
, p. 510 (2007/10/02)
Pentafluorophenyl formate reacts smoothly with N-nucleophiles under mild conditions to give the N-formyl derivatives, whereas O- and S-nucleophiles remain unaffected even in the presence of a tertiary base.
