26343-75-9

Usage

Uses

An impurity of (S)-(-)-Methamphetamine (M258790). Controlled substance.

Upstream product

• 7632-10-2 methamphetamin 
• 67-56-1 methanol 
• 102732-71-8 -(5-phenyl-2-furylmethyl)-amin 
• 102732-72-9 <5-(4-Methoxyphenyl)-2-furylmethyl>-methyl-(1-methyl-2-phenyl-ethyl)-amin 
• 64-18-6 formic acid 
• 123-39-7 N-Methylformamide 
• 103-79-7 1-phenyl-acetone 
• 593-51-1 methylamine hydrochloride 
• 67844-53-5 N-formyl ephedrine 
• 1630-35-9 (1R,2S)-N-<(2-Hydroxy-2-phenyl)-1-methyl-ethyl>-N-methylformamid 
• 103-82-2 phenylacetic acid 
• 1668-82-2 (2S,4S)-3,4-dimethyl-5-phenyl-1,3-oxazolidine 
• 102732-70-7 <5-(4-Chlorphenyl)-2-furylmethyl>-methyl-(1-methyl-2-phenyl-ethyl)-amin 

Relevant academic research and scientific papers

Compositions and Methods for Treating Cocaine, Nicotine, and Methamphetamine Dependence

This invention provides a composition of matter comprising a plurality of cocaine-succinyl-BSA, wherein the average ratio of cocaine-succinyl moieties to BSA is at least 7.0. This invention also provides a composition of matter comprising a plurality of nicotine-5-succinyl-BSA, wherein the average ratio of nicotine-5-succinyl moieties to BSA is at least 7.0. This invention further provides a composition of matter comprising a plurality of methamphetamine-5-succinyl-BSA, wherein the average ratio of methamphetamine-5-succinyl moieties to BSA is at least 7.0. This invention still further provides related pharmaceutical compositions, therapeutic methods, prophylactic methods, synthetic methods, and articles of manufacture.

Characterization of route specific impurities found in methamphetamine synthesized by the Leuckart and reductive amination methods

Impurity profiling of seized methamphetamine can provide very useful information in criminal investigations and, specifically, on drug trafficking routes, sources of supply, and relationships between seizures. Particularly important is the identification of "route specific" impurities or those which indicate the synthetic method used for manufacture in illicit laboratories. Previous researchers have suggested impurities which are characteristic of the Leuckart and reductive amination (Al/Hg) methods of preparation. However, to date and importantly, these two synthetic methods have not been compared in a single study utilizing methamphetamine hydrochloride synthesized in-house and, therefore, of known synthetic origin. Using the same starting material, 1-phenyl-2-propanone (P2P), 40 batches of methamphetamine hydrochloride were synthesized by the Leuckart and reductive amination methods (20 batches per method). Both basic and acidic impurities were extracted separately and analyzed by GC/MS. From this controlled study, two route specific impurities for the Leuckart method and one route specific impurity for the reductive amination method are reported. The intra- and inter-batch variation of these route specific impurities was assessed. Also, the variation of the "target impurities" recently recommended for methamphetamine profiling is discussed in relation to their variation within and between production batches synthesized using the Leuckart and reductive amination routes.

Determination of the synthetic origin of methamphetamine samples by 2H NMR spectroscopy

Samples of methamphetamine, prepared according to the most common synthetic pathways, were submitted to natural-abundance 2H NMR spectroscopy. The deuterium content at the various sites of the molecule was found to depend on its synthetic history. The technique provides a chemical fingerprint of methamphetamine samples and can give hints to trace back the starting materials and the synthetic procedures.

A PROCESS FOR THE PREPARATION OF R-(-)-N, α-DIMETHYLPHENETHYLAMINE (LEVMETAMFETAMINE) OR S-(+)-N, α-DIMETHYLPHENETHYLAMINE (METHAMPHETAMINE) FROM d-EPHEDRINE OR L-EPHEDRINE RESPECTIVELY

A process for synthesis of R-(-)-N, α -Dimethylphenethylamine (Levmetamfetamine, formula I), or S-(+)-N, α - Dimethyl phenethylamine (Methamphetamine, formula II ), from d-ephedrine of formula III or l-ephedrine formula IV, the process comprising the steps of (a) acylating the d- or l-ephedrine base of formula III or formula IV with an acylating agent to make a reaction mixture containing a N- acylated ephedrines of formula V or formula VI ; (b) deoxygenation of N-acylated ephedrines to make the compound of the formula VII or Formula VIII by using Raney Nickel catalyst ; and (c) acid hydrolysis of the above deoxygenated products to get the levmetamfetamine or methamphetamine.

Unusually facile palladium catalysed oxidation of imidazolidines and oxazolidines

An unusually facile palladium catalysed oxidation of imidazolidines is described, affording in good yield, the monoamide of the corresponding diamine or the corresponding imidazolines. Oxazolidines derived from ephedrine react similarly.