16307-14-5

Upstream product

• 83-33-0 inden-1-one 
• 455-19-6 4-Trifluoromethylbenzaldehyde 
• 88-67-5 2-Iodobenzoic acid 
• 214360-65-3 4-trifluoromethylphenylboronic acid pinacol ester 
• 609-67-6 2-Iodobenzoyl chloride 

Downstream Products

• 16307-25-8 2-(4-Trifluoromethyl-benzyl)-1H-indene 
• 47546-05-4 Diethyl-{2-[2-(4-trifluoromethyl-benzyl)-3H-inden-1-yl]-ethyl}-amine 

Relevant academic research and scientific papers

Iridium-catalyzed chemoselective transfer hydrogenation of α, β-unsaturated ketones to saturated ketones in water

A chemoselective iridium-catalyzed transfer hydrogenation of α, β-unsaturated ketones was realized in water. The C[dbnd]C double bonds of 2-benzylidene indanones and analogues were hydrogenated exclusively catalyzed by an iridium complex (0.1 mol%) bearin

Iron-catalyzed chemoselective hydride transfer reactions

A Diaminocyclopentadienone iron tricarbonyl complex has been applied in chemoselective hydrogen transfer reductions. This bifunctional iron complex demonstrated a broad applicability in mild conditions in various reactions, such as reduction of aldehydes over ketones, reductive alkylation of various functionalized amines with functionalized aldehydes and reduction of α,β-unsaturated ketones into the corresponding saturated ketones. A broad range of functionalized substrates has been isolated in excellent yields with this practical procedure.

Ni-Catalyzed Alkene Carboacylation via Amide C-N Bond Activation

We report Ni-catalyzed formal carboacylation of o-allylbenzamides with arylboronic acid pinacol esters. The reaction is triggered by oxidative addition of an activated amide C-N bond to a Ni(0) catalyst and proceeds via alkene insertion into a Ni(II)-acyl bond. The exo-selective carboacylation reaction generates 2-benzyl-2,3-dihydro-1H-inden-1-ones in moderate to high yields (46-99%) from a variety of arylboronic acid pinacol esters and substituted o-allylbenzamides. These results show that amides are practical substrates for alkene carboacylation via amide C-N bond activation, and this approach bypasses challenges associated with alkene carboacylation triggered by C-C bond activation.