16308-17-1Relevant academic research and scientific papers
Asymmetric Synthesis of Enantiopure Pyrrolidines by C(sp3)?H Amination of Hydrocarbons
Darses, Benjamin,Dauban, Philippe,Lazib, Yanis,Retailleau, Pascal,Saget, Tanguy
supporting information, p. 21708 - 21712 (2021/08/30)
The asymmetric synthesis of enantiopure pyrrolidines is reported via a streamlined strategy relying on two sequential C?H functionalizations of simple hydrocarbons. The first step is a regio- and stereoselective catalytic nitrene C?H insertion. Then, a su
Bicyclic piperazines as metabotropic glutatmate receptor antagonists
-
Page/Page column 24, (2008/06/13)
The invention relates to compounds of formula I or pharmaceutically acceptable salts or solvates thereof: where Ar1, A, Hy, R1, m and n are as defined in the description. The invention also includes pharmaceutical compositions and uses of, and processes of making the compounds, as well as methods of medical treatment of mGluR5-mediated disorders.
mGluR5 modulators III
-
Page/Page column 12, (2008/06/13)
The present invention is directed to novel compounds, to a process for their preparation, their use in therapy and pharmaceutical compositions comprising the novel compounds.
MGLUR5 MODULATORS II
-
Page/Page column 18, (2008/06/13)
The present invention is directed to novel compounds, to a process for their preparation, their use in therapy and pharmaceutical compositions comprising the novel compounds.
MGluR5 modulators I
-
Page/Page column 24, (2008/06/13)
The present invention is directed to novel compounds, to a process for their preparation, their use in therapy and pharmaceutical compositions comprising the novel compounds.
Easy preparation of (diacetoxyiodo)arenes from iodoarenes with sodium percarbonate as the oxidant
Zielinska, Agnieszka,Skulski, Lech
, p. 806 - 809 (2007/10/03)
Easy and effective preparations of nearly pure (diacetoxyiodo)arenes, ArI(OAc)2, from iodoarenes, ArI, are reported. In most cases the crude colorless products thus obtained need not be further purified, i.e., by recrystallization. As an example, the PhI(OAc)2 thus prepared was 99% pure (by iodometry).
Syntheses of (diacetoxyiodo)arenes or iodylarenes from iodoarenes, with sodium periodate as the oxidant
Kazmierczak, Pawel,Skulski, Lech,Kraszkiewicz, Lukasz
, p. 881 - 891 (2007/10/03)
Easy, safe, and effective novel methods for preparing either (diacetoxyiodo)-(arenes, ArI(OAc)2, or iodylarenes, ArIO2, from the corresponding iodoarenes, ArI, using sodium periodate as the oxidant are presented in this paper. In order to obtain 2- and 4-iodylbenzoic acids, the respective sodium salts of 2- and 4-iodobenzoic acids should be used as the starting substrates, because mixtures containing the corresponding iodosyl derivatives as the main products along with the intended iodyl compounds are produced from the free parent acids.
