163080-49-7

Basic information

• Product Name: 11-oxo-5,7,8,9,10,11-hexahydrobenzo[4,5]imidazo[1,2-b]isoquinoline-6-carbonitrile
• Synonyms: 11-oxo-5,7,8,9,10,11-hexahydrobenzo[4,5]imidazo[1,2-b]isoquinoline-6-carbonitrile;11-oxo-5,7,8,9,10,11-hexahydrobenzimidazo[1,2-b]isoquinoline-6-carbonitrile
• CAS NO: 163080-49-7
• Molecular Formula: C16H13N3O
• Molecular Weight: 263.29392
• Mol File: 163080-49-7.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 450.3±45.0 °C(Predicted)
• Appearance: /
• Density: 1.39±0.1 g/cm3(Predicted)
• PKA: 0.46±0.40(Predicted)
• CAS DataBase Reference: 11-oxo-5,7,8,9,10,11-hexahydrobenzo[4,5]imidazo[1,2-b]isoquinoline-6-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 11-oxo-5,7,8,9,10,11-hexahydrobenzo[4,5]imidazo[1,2-b]isoquinoline-6-carbonitrile(163080-49-7)
• EPA Substance Registry System: 11-oxo-5,7,8,9,10,11-hexahydrobenzo[4,5]imidazo[1,2-b]isoquinoline-6-carbonitrile(163080-49-7)

Safety Data

• Hazardous Substances Data: 163080-49-7(Hazardous Substances Data)

Upstream product

• 4414-88-4 1H-benzimidazol-2-acetonitrile 
• 1655-07-8 ethyl 2-oxocyclohexane carboxylate 

Downstream Products

• 251983-44-5 11-p-tolylamino-7,8,9,10-tetrahydro-benzo[4,5]imidazo[1,2-b]isoquinoline-6-carbonitrile 
• 163080-53-3 11-chloro-7,8,9,10-tetrahydrobenzimidazo[1,2-b]isoquinoline-6-carbonitrile 

Relevant articles and documents

Benzimidazole condensed ring systems. XI. Synthesis of some substituted cycloalkyl pyrido[1,2-a]benzimidazoles with anticipated antineoplastic activity

As part of a research project on the synthesis of a number of pyrido[1,2-a]benzimidazole derivatives with possible antineoplastic activity, and as a result of the interesting antineoplastic activity recorded for one such compound (NSC 649900), some new cycloalkylpyrido[1,2-a]benzimidazoles were prepared and evaluated for such activity. Compound (7c, NSC 682011) exhibited a good in vitro antineoplastic activity especially against most of the leukaemia cell lines. This compound has been selected by the NCI for further testing in a new in vivo anticancer hollow fibre assay.