251983-44-5

Upstream product

• 106-49-0 p-toluidine 
• 163080-53-3 11-chloro-7,8,9,10-tetrahydrobenzimidazo[1,2-b]isoquinoline-6-carbonitrile 
• 4414-88-4 1H-benzimidazol-2-acetonitrile 
• 163080-49-7 5,7,8,9,10,11-hexahydro-11-oxo-benzimidazo[1,2-b]isoquinoline-6-carbonitrile 
• 1655-07-8 ethyl 2-oxocyclohexane carboxylate 

Relevant academic research and scientific papers

Benzimidazole condensed ring systems. XI. Synthesis of some substituted cycloalkyl pyrido[1,2-a]benzimidazoles with anticipated antineoplastic activity

As part of a research project on the synthesis of a number of pyrido[1,2-a]benzimidazole derivatives with possible antineoplastic activity, and as a result of the interesting antineoplastic activity recorded for one such compound (NSC 649900), some new cycloalkylpyrido[1,2-a]benzimidazoles were prepared and evaluated for such activity. Compound (7c, NSC 682011) exhibited a good in vitro antineoplastic activity especially against most of the leukaemia cell lines. This compound has been selected by the NCI for further testing in a new in vivo anticancer hollow fibre assay.