1630952-94-1Relevant articles and documents
Synthesis, isomerism, and hypotensive activity of thiethane-containing hydrazones of uracilylacetic acid
Meshcheryakova,Kataev,Nikolaeva,Perfilova,Borodin,Tyurenkov
, p. 300 - 307 (2014/06/09)
By the reaction of 2-[6-methyl-1-(thiethane-3-yl)uracil-3-yl]acetic acid hydrazide with aryl aldehydes and acetophenone derivatives, acylhydrazones have been obtained, which exist in DMSO solutions as a mixture of two stereoisomers of an EC=N-isomer, due to the hindered internal rotation around the hydrazide bond. It has been found that the compounds synthesized exhibit a hypotensive activity.