1630984-18-7

Basic information

• Product Name: (S)-1-M-TOLYLETHANAMINE HCL
• Synonyms: [(1S)-1-(3-methylphenyl)ethyl]amine hydrochloride
• CAS NO: 1630984-18-7
• Molecular Formula: C₉H₁₃N*ClH
• Molecular Weight: 171.66716
• Mol File: 1630984-18-7.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: (S)-1-M-TOLYLETHANAMINE HCL(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1-M-TOLYLETHANAMINE HCL(1630984-18-7)
• EPA Substance Registry System: (S)-1-M-TOLYLETHANAMINE HCL(1630984-18-7)

Safety Data

• Hazardous Substances Data: 1630984-18-7(Hazardous Substances Data)

Usage

General Description

(S)-1-M-Tolylethylamine HCl, also known as (S)-1-Methyl-2-phenylethylamine hydrochloride, is a chemical compound with a molecular formula C9H14ClN. It is a salt formed from the amine (S)-1-M-Tolylethylamine and hydrochloric acid. (S)-1-M-TOLYLETHANAMINE HCL is commonly used in the pharmaceutical industry as a chiral building block for the synthesis of various drugs and biologically active compounds. Additionally, it has potential applications in medicinal chemistry, particularly in the development of new psychoactive substances and central nervous system drugs. Apart from its synthetic applications, (S)-1-M-Tolylethylamine HCl is also of interest in research and academic studies related to organic chemistry and drug discovery. Overall, this compound has important industrial and scientific significance due to its diverse applications in the field of pharmaceuticals and organic synthesis.

Upstream product

• 585-74-0 3-Methylacetophenone 
• 1164111-44-7 C₉H₁₁N*ClH 

Downstream Products

• 138457-18-8 (-)-(S)-1-(3-methylphenyl)ethylamine 

Relevant articles and documents

Chiral Bronsted Acids Catalyze Asymmetric Additions to Substrates that Are Already Protonated: Highly Enantioselective Disulfonimide-Catalyzed Hantzsch Ester Reductions of NH-Imine Hydrochloride Salts

While imines are frequently used substrates in asymmetric Bronsted acid catalysis, their corresponding salts are generally considered unsuitable reaction partners. Such processes are challenging because they require the successful competition of a catalytic amount of a chiral anion with a stoichiometric amount of an achiral one. We now show that enantiopure disulfonimides enable the asymmetric reduction of N-H imine hydrochloride salts using Hantzsch esters as hydrogen source. Our scalable reaction delivers crystalline primary amine salts in great efficiency and enantioselectivity and the discovery suggests potential of this approach in other Bronsted acid catalyzed transformations of achiral iminium salts. Kinetic studies and acidity data suggest a bifunctional catalytic activation mode.

Rhodium-catalyzed asymmetric hydrogenation of unprotected NH imines assisted by a thiourea

Asymmetric hydrogenation of unprotected NH imines catalyzed by rhodium/bis(phosphine)-thiourea provided chiral amines with up to 97% yield and 95% ee. 1HNMR studies, coupled with control experiments, implied that catalytic chloride-bound intermediates were involved in the mechanism through a dual hydrogen-bonding interaction. Deuteration experiments proved that the hydrogenation proceeded through a pathway consistent with an imine.