163181-22-4Relevant academic research and scientific papers
Synthesis and Absolute Configuration of Chiral Piperazines Related to GBR 12909 as Dopamine Reuptake Inhibitors
Matecka, Dorota,Rice, Kenner C.,Rothman, Richard B.,Costa, Brian R. de,Glowa, John R.
, p. 43 - 53 (2007/10/03)
Novel GBR 12909 analogs, enantiomeric trans-2,5-dimethyl-1-{2-[bis-(4-fluorophenyl)methoxy]ethyl}-4-(3-phenylpropyl)piperazines (+)- and (-)-4 were synthesized. Isomer (-)-4 displayed high affinity (IC 50=3.62 nM) and 34.5 fold enantioselectivity ratio at
