1632-49-1

Usage

Derivative of pyrrole

A five-membered aromatic ring with a nitrogen atom The compound is based on a pyrrole structure, which consists of a five-membered ring with one nitrogen atom, providing the basis for its aromatic and chelating properties.

Two carboxylic acid groups

Potential chelating agent The presence of two carboxylic acid groups in the molecule allows it to form coordination compounds with metal ions, making it a potential chelating agent.

Diphenyl groups

Stability and hydrophobic properties The addition of two phenyl groups to the pyrrole ring provides stability to the molecule and introduces hydrophobic properties, which can be useful in various applications.

Applications in materials science

The compound's unique structure and properties make it valuable for research and development in materials science, potentially leading to new materials with specialized functions.

Organic synthesis

1H-Pyrrole-2,5-dicarboxylic acid, 3,4-diphenylcan be used as a building block or intermediate in the synthesis of more complex organic molecules, contributing to the development of new compounds and chemical reactions.

Pharmaceutical research

The chelating properties and stability of the compound make it a potential candidate for use in pharmaceutical applications, such as the development of new drugs or drug delivery systems.

Various chemical and industrial purposes

The compound's unique structure and properties can be applied in a wide range of chemical and industrial processes, making it a valuable addition to the field.

Upstream product

• 156-06-9 2-oxo-3-(phenyl)propionic acid 
• 5410-10-6 dimethyl 2,2'-(acetylazanediyl)diacetate 
• 134-81-6 benzil 

Downstream Products

• 1632-48-0 3,4-diphenyl-1H-pyrrole 
• 1321620-89-6 N²,N⁵-bis(6-methylpyridin-2-yl)-3,4-diphenyl-1H-pyrrole-2,5-dicarboxamide 
• 1321620-90-9 N²,N⁵-bis(7-methyl-1,8-naphthyridin-2-yl)-3,4-diphenyl-1H-pyrrole-2,5-dicarboxamide 
• 1058152-04-7 N,N'-bis(pyridin-2-ylmethyl)-3,4-diphenyl-1H-pyrrole-2,5-carboxamide 
• 95038-26-9 1-methyl-3,4-diphenyl-2,5-bis(hydroxymethyl)pyrrole bis 
• 103776-14-3 1-methyl-3,4-diphenyl-2,5-bis(hydroxymethyl)pyrrole 
• 566932-85-2 N,N'-bis(3,5-dinitrophenyl)-3,4-diphenyl-1H-pyrrole-2,5-dicarboxamide 
• 365214-49-9 N₂,N₅-dibutyl-3,4-diphenyl-1H-pyrrole-2,5-dicarboxamide 
• 365214-50-2 N₂,N₅,3,4-tetraphenyl-1H-pyrrole-2,5-dicarboxamide 
• 365214-51-3 3,4-diphenylpyrrole-2,5-dicarboxylic acid chloride 
• 103776-11-0 dimethyl 1-methyl-3,4-diphenylpyrrole-2,5-dicarboxylate 

Relevant academic research and scientific papers

Structure-activity relationships study of neolamellarin A and its analogues as hypoxia inducible factor-1 (HIF-1) inhibitors

The novel marine pyrrole alkaloid neolamellarin A derived from sponge has been shown to inhibit hypoxia-induced HIF-1 activity. In this work, we designed and synthesized neolamellarin A and its series of derivatives by a convergent synthetic strategy. The HIF-1 inhibitory activity and cytotoxicity of these compounds were evaluated in Hela cells by dual-luciferase reporter gene assay and MTT assay, respectively. The results showed that neolamellarin A 1 (IC50 = 10.8 ± 1.0 μM) and derivative 2b (IC50 = 11.9 ± 3.6 μM) had the best HIF-1 inhibitory activity and low cytotoxicity. Our SAR research focused on the effects of key regions aliphatic carbon chain length, aromatic ring substituents and C-7 substituent on biological activity, providing a basis for the subsequent research on the development of novel pyrrole alkaloids as HIF-1 inhibitors and design of small molecule probes for target protein identification.

Synthetic hosts for molecular recognition of ureas

Four hosts (7-10) containing 2,6-bisamidopyridine- and 2,5-bisamidopyrrole- bearing pyridyl or 1,8-naphthyridyl groups have been prepared and their structures studied by a combination of multinuclear NMR spectroscopy and X-ray crystallography. Their behav

Synthesis of 1',2',3',4',5'-pentamethyl-3,4-diphenylazaferrocene and its enantioselective C-2 functionalization via (-)-sparteine-mediated lithiation

Lithiation of 1',2',3',4',5'-pentamethyl-3,4-diphenylazaferrocene (9) with sec-BuLi/(-)-sparteine (2) in Et2O at -78 °C followed by quenching with electrophiles gave the C-2 functionalized azaferrocenes (17) in good enantioselectivities (up to