163210-45-5Relevant academic research and scientific papers
Tricyclic pharmacophore-based molecules as novel integrin αvβ3 antagonists. Part 1: Design and synthesis of a lead compound exhibiting αvβ3/ αIIbβ3 dual antagonistic activity
Kubota, Dai,Ishikawa, Minoru,Yamamoto, Mikio,Murakami, Shoichi,Hachisu, Mitsugu,Katano, Kiyoaki,Ajito, Keiichi
, p. 2089 - 2108 (2007/10/03)
In order to generate novel compounds with integrin α vβ3-antagonistic activity together with antiplatelet activity, tricyclic pharmacophore-based molecules were designed and synthesized. Although piperazine-containing compounds initially prepared were selective αIIbβ3 antagonists, replacement of piperazine with piperidine furnished a potent αvβ3/ αIIbβ3 dual antagonist. Structure-activity relationship (SAR) studies provided clues for further development of tricyclic pharmacophore-based integrin antagonists.
