163217-70-7

Basic information

• Product Name: P-HYDROXY ATORVASTATIN LACTONE
• Synonyms: P-HYDROXY ATORVASTATIN LACTONE;5-(4-Fluorophenyl)-N-(4-hydroxyphenyl)-2-(1-Methylethyl)-4-phenyl-1-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1H-pyrrole-3-carboxaMide;5-(4-fluorophenyl)-1-(2-((2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-N-(4-hydroxyphenyl)-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxaMide;4-Hydroxy Atorvastatin Lactone (EP);Atorvastatin 4-Hydroxy Lactone;5-(4-Fluorophenyl)-1-(2-((2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl)-ethyl)-N-(4-hydroxyp
• CAS NO: 163217-70-7
• Molecular Formula: C33H33FN2O5
• Molecular Weight: 556.62
• Product Categories: Various Metabolites and Impurities;Metabolites
• Mol File: 163217-70-7.mol
• Article Data: 2

Chemical Properties

• Melting Point: 103-106°C
• Appearance: /
• Storage Temp.: -20°C Freezer
• CAS DataBase Reference: P-HYDROXY ATORVASTATIN LACTONE(CAS DataBase Reference)
• NIST Chemistry Reference: P-HYDROXY ATORVASTATIN LACTONE(163217-70-7)
• EPA Substance Registry System: P-HYDROXY ATORVASTATIN LACTONE(163217-70-7)

Safety Data

• Hazardous Substances Data: 163217-70-7(Hazardous Substances Data)

Usage

Chemical Properties

Pale-Yellow to Tan Solid

Uses

Different sources of media describe the Uses of 163217-70-7 differently. You can refer to the following data:
1. A metabolite of Atorvastin, a selective, competitive HMG-CoA reductase inhibitor. Atorvastin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia
2. A metabolite of Atorvastatin, a selective, competitive HMG-CoA reductase inhibitor. Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia.
3. Atorvastatin metabolite

Upstream product

• 103-50-4 dibenzyl ether 
• 163217-68-3 tert-butyl 2-((4R,6R)-6-(2-(3-((4-(benzyloxy)phenyl)carbamoyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate 
• 265989-36-4 tert-butyl 2-((4R,6R)-6-(2-(2-(4-fluorophenyl)-4-((4-hydroxyphenyl)carbamoyl)-5-isopropyl-3-phenyl-1H-pyrrol-1-yl)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate 
• 163217-66-1 2-benzylidene-N-(4-(benzyloxy)phenyl)-4-methyl-3-oxopentanamide 
• 265989-30-8 N-(4-(benzyloxy)phenyl)-4-methyl-3-oxopentanamide 
• 214217-88-6 p-Hydroxyatorvastatin 
• 163217-67-2 N-(4-(benzyloxy)phenyl)-2-(2-(4-fluorophenyl)-2-oxo-1-phenylethyl)-4-methyl-3-oxopentanamide 
• 6373-46-2 p-benzyloxyaniline 

Relevant articles and documents

Synthesis of deuterium-labeled atorvastatin and its metabolites for use as internal standards in a LC/MS/MS method developed for quantitation of the drug and its metabolites in human serum

D5-labeled isotopomers of atorvastatin, atorvastatin lactone and its hydroxy metabolites were synthesized as internal standards for use in a LC/MS/MS method developed for the simultaneous quantitative determination of atorvastatin and its hydroxy metabolites in human serum. d5-Atorvastatin and d5-atorvastatin lactone were prepared from d5-aniline whereas their corresponding hydroxy metabolites were synthesized using d5-benzaldehyde.