163220-69-7

Basic information

• Product Name: 2,2,2-trichloro-1-(1H-pyrrolo[2,3-b]pyridin-3-yl)ethanone
• Synonyms: 2,2,2-trichloro-1-(1H-pyrrolo[2,3-b]pyridin-3-yl)ethanone;2,2,2-Trichloro-1-{1H-pyrrolo-[2,3-b]pyridin-3-yl}ethan-1-one
• CAS NO: 163220-69-7
• Molecular Formula: C9H5Cl3N2O
• Molecular Weight: 263.5078
• Mol File: 163220-69-7.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2,2,2-trichloro-1-(1H-pyrrolo[2,3-b]pyridin-3-yl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,2-trichloro-1-(1H-pyrrolo[2,3-b]pyridin-3-yl)ethanone(163220-69-7)
• EPA Substance Registry System: 2,2,2-trichloro-1-(1H-pyrrolo[2,3-b]pyridin-3-yl)ethanone(163220-69-7)

Safety Data

• Hazardous Substances Data: 163220-69-7(Hazardous Substances Data)

Usage

General Description

2,2,2-trichloro-1-(1H-pyrrolo[2,3-b]pyridin-3-yl)ethanone is a complex chemical compound that belongs to the class of organic compounds known as aryl chlorides. It's a chemical derivative from pyrrolopyridines family, featuring a pyrrolo[2,3-b]pyridine moiety bound to a 2,2,2-trichloroethanone unit. Its main applications or utilities are not widely documented, suggesting that it may be primarily used in research or specific industrial processes. Its safe handling and any potential risks to health or the environment would be determined by its physicochemical properties, as with any chemical compound.

Upstream product

• 271-63-6 7-Azaindole 
• 76-02-8 trifluoroacetyl chloride 

Downstream Products

• 74420-16-9 1H-pyrrolo<2,3-b>pyridine-3-carboxamide 
• 156270-06-3 7-azaindolyl-3-carboxylic acid 
• 808137-94-2 1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid methyl ester 
• 310887-39-9 1H-pyrrolo[2,3-b]pyridine-3-carbohydrazide 
• 1210437-60-7 C₁₆H₁₂FN₅O 

Relevant articles and documents

Strategies to develop selective CB2 receptor agonists from indole carboxamide synthetic cannabinoids

Activation of the CB2 receptor is an attractive therapeutic strategy for the treatment of a wide range of inflammatory diseases. However, receptor subtype selectivity is necessary in order to circumvent the psychoactive effects associated with activation of the CB1 receptor. We aimed to use potent, non-selective synthetic cannabinoids designer drugs to develop selective CB2 receptor agonists. Simple structural modifications such as moving the amide substituent of 3-amidoalkylindole synthetic cannabinoids to the 2-position and bioisosteric replacement of the indole core to the 7-azaindole scaffold are shown to be effective and general strategies to impart receptor subtype selectivity. 2-Amidoalkylindole 16 (EC50 CB1 > 10 μM, EC50 CB2 = 189 nM) and 3-amidoalkyl-7-azaindole 21 (EC50 CB1 > 10 μM, EC50 = 49 nM) were found to be potent and selective agonists with favourable physicochemical properties. Docking studies were used to elucidate the molecular basis for the observed receptor subtype selectivity for these compounds.

PYRIDINONYL PDK1 INHIBITORS

The present invention provides pyridinonyl PDKl inhibitors and methods of treating cancer using the same.