2,2,2-trichloro-1-(1H-pyrrolo[2,3-b]pyridin-3-yl)ethanone

Base Information

• Chemical Name: 2,2,2-trichloro-1-(1H-pyrrolo[2,3-b]pyridin-3-yl)ethanone
• CAS No.: 163220-69-7
• Molecular Formula: C9H5Cl3N2O
• Molecular Weight: 263.51
• Hs Code.: 2933990090
• Mol file: 163220-69-7.mol

Synonyms:2,2,2-trichloro-1-{1H-pyrrolo[2,3-b]pyridin-3-yl}ethanone;

Chemical Property of 2,2,2-trichloro-1-(1H-pyrrolo[2,3-b]pyridin-3-yl)ethanone

Chemical Property:

• PSA: 45.75000
• LogP: 3.11580

Purity/Quality:

97% ^*data from raw suppliers

2,2,2-Trichloro-1-{1H-pyrrolo-[2,3-b]pyridin-3-yl}ethan-1-one 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,2,2-trichloro-1-(1H-pyrrolo[2,3-b]pyridin-3-yl)ethanone

There total 2 articles about 2,2,2-trichloro-1-(1H-pyrrolo[2,3-b]pyridin-3-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

7-Azaindole (271-63-6) + trifluoroacetyl chloride (76-02-8) → 2,2,2-trichloro-1-(1H-pyrrolo[2,3-b]pyridin-3-yl)ethanone (163220-69-7)

Guidance literature:

7-Azaindole; With aluminum (III) chloride; In dichloromethane; at 0 ℃; for 0.25h;

trifluoroacetyl chloride; In dichloromethane; at 20 ℃; for 4h;

DOI:10.1016/j.ejmech.2019.07.036

Reference yield:

→ 2,2,2-trichloro-1-(1H-pyrrolo[2,3-b]pyridin-3-yl)ethanone (163220-69-7)

Guidance literature:

Reference yield: 100.0%

2,2,2-trichloro-1-(1H-pyrrolo[2,3-b]pyridin-3-yl)ethanone (163220-69-7) → 7-azaindolyl-3-carboxylic acid (156270-06-3)

Guidance literature:

With sodium hydroxide; In water; at 20 ℃; for 6h;

DOI:10.1016/j.ejmech.2019.07.036

upstream raw materials:

7-Azaindole

trifluoroacetyl chloride

Downstream raw materials:

1H-pyrrolo<2,3-b>pyridine-3-carboxamide

7-azaindolyl-3-carboxylic acid

1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid methyl ester

C₁₆H₁₂FN₅O