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163253-35-8

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163253-35-8 Usage

Description

The fluoroquinolone antibacterial agent sitafloxacin hydrate was developed by Daiichi Sankyo and was approved and launched last year in Japan. Sitafloxacin’s mode of action is through inhibition of DNA gyrase and topoisomerase IV. It is indicated for the treatment of inflammatory infections such as laryngopharyngitis, adenoiditis, acute bronchitis, pneumonia, secondary infections due to chronic respiratory lesions, cystitis, pyelonephritis, urethritis, cervicitis, otitismedia, sinusitis, periodontitis, and pericoronitis and jaw inflammation. Due to its broad spectrum of potent antibacterial activity, sitafloxacin is expected to be clinically effective in treating severe cases of bacterial infection, relapse/recrudescence of infection and infections in which resistant bacteria are suspected to be the cause.

Chemical Properties

Off-White Solid

Uses

Different sources of media describe the Uses of 163253-35-8 differently. You can refer to the following data:
1. Sitafloxacin is a new-generation, broad-spectrum oral fluoroquinolone antibiotic. It is very active against many Gram-positive, Gram-negative and anaerobic clinical isolates, including strains resistant to other fluoroquinolones, was recently approved in
2. Antibacterial

Synthesis

The optically pure fluorocyclopropylamine 111 intermediate was prepared as described in thescheme. Condensation of diphenylmethyl amine 104 with acetaldehyde followed by treatment with trichloromethyl chloroformate in the presence of triethylamine gave N-vinyl carbamoyl chloride 105 in 53% yield. This intermediate was reacted with sodium benzyloxide (generated in situ) to afford N-vinylcarbamate 106 in 82% yield. Fluorocyclopropanation of 106 with zinc– monofluorocarbenoid generated from fluorodiiodomethane and diethylzinc provided N-(2-fluorocyclopropyl)carbamate 107 in 90% yield and with a diastereomeric ratio of 93:7 favoring the cis-isomer. Hydrogenolysis of the CBz and the diphenylmethyl groups was accomplished with catalytic 10% palladium on charcoal and was followed by treatment with TsOH to afford dl-108 as its tosylate salt. Acylation of dl- 108 TsOH with l-menthyl chloroformate gave a 1:1 mixture of the diastereomeric carbamate 109 which upon four repeated recrystallizations from hexane/ethyl acetate afforded optically pure 110 in 26% yield. Acidic hydrolysis of 110 furnished 111 as its HCl salt in 88% yield.

Check Digit Verification of cas no

The CAS Registry Mumber 163253-35-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,3,2,5 and 3 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 163253-35:
(8*1)+(7*6)+(6*3)+(5*2)+(4*5)+(3*3)+(2*3)+(1*5)=118
118 % 10 = 8
So 163253-35-8 is a valid CAS Registry Number.
InChI:InChI=1/C19H18ClF2N3O3.H2O/c20-14-15-8(17(26)9(18(27)28)5-25(15)12-4-10(12)21)3-11(22)16(14)24-6-13(23)19(7-24)1-2-19;/h3,5,10,12-13H,1-2,4,6-7,23H2,(H,27,28);1H2/t10-,12?,13+;/m0./s1

163253-35-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name Sitafloxacin Sesquihydrate

1.2 Other means of identification

Product number -
Other names Sitafloxacin hydrate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:163253-35-8 SDS

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