163299-06-7Relevant academic research and scientific papers
Synthesis method of 2-phenyl-4-p-hydroxy phenylthiazole
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Paragraph 0016, (2017/10/07)
The invention belongs to the technical field of organic chemical synthesis, and relates to a high-efficiency and simple synthesis method of a 2-phenyl-4-p-hydroxy phenylthiazole compound. The synthetic steps are as follows: dissolving p-hydroxyphenylaceto
Compounds enhancing antitumor activity of other cytotoxic agents
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, (2008/06/13)
This invention relates to certain heterocyclic compounds and their pharmaceutically acceptable salts, which are useful for sensitizing multidrug-resistant tumor cells to anticancer agents and multidrug resistant forms of malaria, tuberculosis, leishmania and amoebic dysentery to chemotherapeutants. The compounds and their pharmaceutically acceptable salts are also inhibitors of the active drug transport capability of P-glycoprotein which is encoded by the human MDR1 gene, as well as of certain other related ATP-binding-cassette transporters from eukaryotic and prokaryotic organisms (e.g., pfmdr from Plasmodium falciprum, and murine mdr1 and mdr3 gene products).
