16335-26-5

Upstream product

• 174636-71-6 3-methyl-2-phenylquinoline-4-carbonyl chloride 
• 133145-92-3 1-phenylpropan-1-one O-acetyl oxime 
• 91-56-5 indole-2,3-dione 

Downstream Products

• 127459-32-9 4-amino-3-methyl-2-phenylquinoline 

Relevant academic research and scientific papers

I2-Triggered Reductive Generation of N-Centered Iminyl Radicals: An Isatin-to-Quinoline Strategy for the Introduction of Primary Amides

An efficient and alternative isatin-to-quinoline strategy illustrates the metal-like behavior of molecular iodine in the N?O reduction of ketoxime acetates. This process involves N?O/C?N bond cleavages and C?C/C?N bond formation to furnish pharmacologically significant quinoline-4-carboxamide derivatives. In this process, metal catalysts and extra oxidants are unnecessary. Mechanistic studies confirm the crucial role of molecular iodine in the iminyl radical generation process, in that molecular iodine can catalyze single-electron reduction coupling reactions in a manner similar to transition metals. (Figure presented.).

Synthetic method of quinoline-4-formamides compound

The invention discloses a synthetic method of a quinoline-4-formamides compound, and belongs to the technical field of organic synthesis. The the invention is characterized in that the synthetic method of the quinoline-4-formamides compound comprises the following steps: dissolving an oxime ester acetate compound and isatin or a derivative of the oxime ester acetate compound and the isatin in a solvent; then adding a catalyst and alkali to carry out reaction at 100 to 130 DEG C in a sealing tube to prepare the quinoline-4-formamides compound. A synthetic process of the synthetic method disclosed by the invention is simple and high-efficient; through one-pot series connection reaction, the quinoline-4-formamides compound is directly prepared in one step, so that resource waste and environment pollution caused by the use of a plurality of reagents in multi-step reaction, purification treatment on intermediates obtained in all reaction steps and the like are avoided, raw materials are cheap and easy to get or the raw materials are easy to prepare; reaction conditions are mild, and a substrate has a wide application range.