16336-29-1 Usage
Description
H-GLY-ONP HCL is a chemical compound consisting of hydroxyproline-glycine-ortho-nitrophenol hydrochloride, which is a combination of an amino acid found in collagen (hydroxyproline), the simplest amino acid (glycine), and a chemical compound used in organic synthesis and as a pH indicator (ortho-nitrophenol). The hydrochloride salt form is commonly used in peptide synthesis and as a reagent for detecting protease activity. H-GLY-ONP HCL is significant for biochemical research, particularly in the study of collagen and protein structure and function.
Uses
Used in Biochemical Research:
H-GLY-ONP HCL is used as a research compound for studying collagen and protein structure and function, providing insights into their biological roles and potential applications.
Used in Peptide Synthesis:
In the field of organic chemistry, H-GLY-ONP HCL is used as a building block in peptide synthesis, allowing for the creation of various peptide sequences for research and potential therapeutic development.
Used in Detection of Protease Activity:
H-GLY-ONP HCL is utilized as a reagent for detecting protease activity, which is essential for understanding enzymatic processes and the regulation of protein function in biological systems.
Check Digit Verification of cas no
The CAS Registry Mumber 16336-29-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,6,3,3 and 6 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 16336-29:
(7*1)+(6*6)+(5*3)+(4*3)+(3*6)+(2*2)+(1*9)=101
101 % 10 = 1
So 16336-29-1 is a valid CAS Registry Number.
16336-29-1Relevant articles and documents
Convenient high yielding gram scale solution synthesis of methionine-enkephalin
Masiukif.wicx, Elzbieta,Rzeszotarska, Barbara
, p. 1672 - 1675 (1998)
A simple, large-scale synthesis of a cytokine, methionine-enkephalin, Tyr-Gly-Gly-Phe-Met, has been elaborated. Classical solution peptide chemistry methods without protection of amino acid side-chain functions and l+(2+2) segment condensation were used. A nine-step synthesis from commercial amino acid derivatives was developed with yields ranging from 86% to 99%, averaging 92%. The purity of all intermediates was found to be 99.0-100% by HPLC. The process has been used to prepare greater than 150 g quantities of the pentapeptide as a monohydrate of 100% purity. Hydantoin formation was observed during saponification of Boc-TyrGly-Gly-Phe-Met-OMe and minimised.
