163380-04-9Relevant academic research and scientific papers
HYDROXY-SUBSTITUTED AZETIDINONE COMPOUNDS USEFUL AS HYPOCHOLESTEROLEMIC AGENTS
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, (2008/06/13)
Hydroxy-substituted azetidinone hypocholesterolemic agents of the formula or a pharmaceutically acceptable salt thereof, wherein: Ar1 and Ar2 are aryl or R4 -substituted aryl; Ar3 is aryl or R5-substituted aryl; X, Y and Z are -CH2 -, -CH(lower alkyl)- or
Combinations of hydroxy-substituted azetidinone compounds and HMG CoA Reductase Inhibitors
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, (2008/06/13)
Hydroxy-substituted azetidinone hypocholesterolemic agents of the formula STR1 or a pharmaceutically acceptable salt thereof, wherein: Ar1 and Ar2 are aryl or R4 -substituted aryl; Ar3 is aryl or R5 -
Stereoselective synthesis and biological activity of cis azetidinones as cholesterol absorption inhibitors
McKittrick, Brian A.,Ma, Ke,Dugar, Sundeep,Clader, John W.,Davis Jr., Harry,Czarniecki, Michael,McPhail, Andrew T.
, p. 1947 - 1950 (2007/10/03)
The C-3 sidechain of azetidinones related to SCH 48461 was modified by introducing a hydroxyl group at the 1' position. This led to the discovery of the cis azetidinone 2c, which had improved CAI activity. Compound 2c was prepared using a selective reduction and silane mediated debromination to control the relative stereochemistry of the three centers.
