19340-69-3Relevant academic research and scientific papers
Microwave-mediated synthesis of 3-unsubstituted β-lactams with aqueous trimethylborane
Yadav, Ram Naresh,Banik, Indrani,Banik, Bimal Krishna
, p. 1381 - 1384 (2020/06/27)
A new microwave-induced method for the preparation of 3-unsubstituted β-lactams is explored via aqueous trimethylborane-mediated reaction of the corresponding xanthates.
Selective synthesis of β-amino esters and β-lactams by rhodium-catalyzed reformatsky-type reaction
Kanai, Kazuo,Wakabayashi, Hitoshi,Honda, Toshio
, p. 47 - 51 (2007/10/03)
β-Amino esters and β-lactams are synthesized selectively from aldimines and ethyl bromoacetate by applying a simply modified rhodium-catalyzed Reformatsky-type reaction.
Differential effects of stereochemistry and C-4 substituents on the enantioselectivity of PLE and PPL catalysed hydrolysis of 3,4-disubstituted β-lactams
Basak, Amit,Mahato, Tapan,Bhattacharya, Gautam,Mukherjee, Ballari
, p. 643 - 646 (2007/10/03)
Pig Liver Esterase (PLE) and Pig Pancreas Lipase (PPL)catalysed hydrolysis of (±) trans-3-carbethoxy and (±)cis-3-acetoxymethyl 4-substituted β-lactams revealed interesting dependence on C-3, C-4 stereochemistry and nature of C-4 substituents.
(-)-SCH 57939: Synthesis and pharmacological properties of a potent, metabolically stable cholesterol absorption inhibitor
Kirkup, Michael P.,Rizvi, Razia,Shankar, Bandarpalle B.,Dugar, Sundeep,Clader, John W.,McCombie, Stuart W.,Lin, Sue-Ing,Yumibe, Nathan,Huie, Keith,Van Heek, Margaret,Compton, Douglas S.,Davis Jr., Harry R.,McPhail, Andrew T.
, p. 2069 - 2072 (2007/10/03)
Previous SAR studies of C-3 side chain modified analogs of (-)-SCH 48461, as well as information concerning the metabolic stability this series, enabled us to design a cholesterol absorption inhibitor (i.e., (-) 2a, SCH 57939) with tenfold higher potency and greatly enhanced metabolic stability. The synthesis and pharmacological profile, including the role of relative stereochemistry at both the C3 and 1' positions in determining the SAR of these compounds, will be discussed.
A New Synthesis of β-Phenylaminothioesters and β-Lactams Via Base-Induced Ring-Opening of 2-Phenyl-3-Aryl-5-Phenyl-Thioisoxazolidines
Nunno, Leonardo Di,Scilimati, Antonio
, p. 10965 - 10976 (2007/10/02)
1,3-Dipolar cycloaddition of phenyl vinyl sulfide to aryl N-phenyl, N-methyl, or N-t-butylnitrones affords 2-phenyl(or 2-methyl or 2-t-butyl)-3-aryl-5-phenylthioisoxazolidines according to the regioselectivity already known for the cycloaddition of not hi
