163457-22-5

Basic information

• Product Name: 1-CBZ-3,3-DIFLUOROPYRROLIDINE
• Synonyms: 1-CBZ-3,3-DIFLUOROPYRROLIDINE;Benzyl 3,3-difluoropyrrolidine-1-carboxylate
• CAS NO: 163457-22-5
• Molecular Formula: C₁₂H₁₃F₂NO₂
• Molecular Weight: 241.23
• Product Categories: pharmacetical
• Mol File: 163457-22-5.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 321°C at 760 mmHg
• Flash Point: 147.9°C
• Appearance: /
• Density: 1.26g/cm³
• Vapor Pressure: 0.000307mmHg at 25°C
• Refractive Index: 1.526
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-CBZ-3,3-DIFLUOROPYRROLIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-CBZ-3,3-DIFLUOROPYRROLIDINE(163457-22-5)
• EPA Substance Registry System: 1-CBZ-3,3-DIFLUOROPYRROLIDINE(163457-22-5)

Safety Data

• Hazardous Substances Data: 163457-22-5(Hazardous Substances Data)

Usage

Chemical Family

Belongs to the pyrrolidine family

Versatility

Acts as a versatile building block in organic synthesis

Industry Applications

Widely used in pharmaceutical and agrochemical industries

Reactivity

Known for its unique reactivity

Intermediate Role

Commonly used as a key intermediate in the synthesis of various biologically active compounds

Substituents

Contains 3,3-difluoro substituents

Medicinal Chemistry

Valuable tool in medicinal chemistry

Enhancement

Enhances the biological activity and pharmacokinetic properties of the final compounds

Field Importance

Important compound in drug discovery and development

InChI:InChI=1/C12H13F2NO2/c13-12(14)6-7-15(9-12)11(16)17-8-10-4-2-1-3-5-10/h1-5H,6-9H2

Upstream product

• 501-53-1 benzyl chloroformate 
• 100858-33-1 (3R)-3-hydroxy-pyrrolidine-1-carboxylic acid benzyl ester 
• 130312-02-6 benzyl 3-oxopyrrolidine-1-carboxylate 

Downstream Products

• 316131-01-8 3,3-difluoropyrrolidine 

Relevant articles and documents

Aminodifluorosulfinium salts: Selective fluorination reagents with enhanced thermal stability and ease of handling

Diethylaminodifluorosulfinium tetrafluoroborate (XtalFluor-E) and morpholinodifluorosulfinium tetrafluoroborate (XtalFluor-M) are crystalline fluorinating agents that are more easily handled and significantly more stable than Deoxo-Fluor, DAST, and their analogues. These reagents can be prepared in a safer and more cost-efficient manner by avoiding the laborious and hazardous distillation of dialkylaminosulfur trifluorides. Unlike DAST, Deoxo-Fluor, and Fluolead, XtalFluor reagents do not generate highly corrosive free-HF and therefore can be used in standard borosilicate vessels. When used in conjunction with promoters such as Et3N3HF, Et3N2HF, or DBU, XtalFluor reagents effectively convert alcohols to alkyl fluorides and carbonyls to gem-difluorides. These reagents are typically more selective than DAST and Deoxo-Fluor and exhibit superior performance by providing significantly less elimination side products.

HETEROCYCLIC CETP INHIBITORS

Compounds of formula Ia and Ib wherein A, B, C and R1 are described herein.

1,2,4-OXADIAZOLE DERIVATIVES AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES

The present invention is directed to novel 1,2,4-oxadiazole derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme ("DP-IV inhibitors") and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.