1634722-02-3

Upstream product

• 100-58-3 phenylmagnesium bromide 
• 37167-62-7 bromo-phenyl-acetic acid methyl ester 
• 100-39-0 benzyl bromide 
• 23465-73-8 3-Phenyl-1,2,3,4-tetrahydroquinoxalin-2-one 
• 95-54-5 1,2-diamino-benzene 

Downstream Products

• 1634721-97-3 3-(4-benzyl-3-phenyl-2-oxo-3,4-dihydro-2H-quinoxalin-1-yl)propionic acid ethyl ester 
• 1634721-91-7 9-benzyl-10-phenyl-3,4,10,10a-tetrahydro-2H,9H-1-oxa-4a,9-diazaphenanthrene 

Relevant academic research and scientific papers

Visible-light-accelerated amination of quinoxalin-2-ones and benzo[1,4]oxazin-2-ones with dialkyl azodicarboxylates under metal and photocatalyst-free conditions

A direct sp3C-H amination of cyclic amines (dihydroquinoxalinones and dihydrobenzoxazinones) with dialkyl azo dicarboxylates accelerated by visible-light irradiation under metal and photocatalyst-free conditions is described. This protocol features very mild reaction conditions for the synthesis of aminal quinoxaline and benzoxazine derivatives with good to high yields (up to 99%). These aminal derivatives respresent versatile building blocks for the divergent synthesis of quinoxalin-2-one derivatives.

Synthesis of 9,10-substituted 3,4,10,10a-tetrahydro-2H,9H-1-oxa-4a,9- diazaphenanthrenes by reductive cyclization method

Commercially available o-phenylenediamine (1) was treated with methyl α-bromo-α-aryl acetate to obtain 3-aryl-3,4-dihydro-1Hquinoxalin- 2-one (2). The latter was reacted with benzyl bromide to obtain 4-benzyl-3-aryl-3,4-dihydro-1H-quinoxalin-2-one (3). Tr