163486-20-2

Basic information

• Product Name: (S)-ethyl 2-(2-(2-amino-3-phenylpropanamido)thiazol-4-yl)acetate
• Synonyms: (S)-ethyl 2-(2-(2-amino-3-phenylpropanamido)thiazol-4-yl)acetate
• CAS NO: 163486-20-2
• Molecular Weight: 333.411
• Mol File: 163486-20-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-ethyl 2-(2-(2-amino-3-phenylpropanamido)thiazol-4-yl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-ethyl 2-(2-(2-amino-3-phenylpropanamido)thiazol-4-yl)acetate(163486-20-2)
• EPA Substance Registry System: (S)-ethyl 2-(2-(2-amino-3-phenylpropanamido)thiazol-4-yl)acetate(163486-20-2)

Safety Data

• Hazardous Substances Data: 163486-20-2(Hazardous Substances Data)

Upstream product

• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 63-91-2 L-phenylalanine 
• 163486-55-3 (S)-ethyl 2-(2-(2-(tert-butoxycarbonylamino)-3-phenylpropanamido)thiazol-4-yl)acetate 

Relevant articles and documents

Design, synthesis, and biological activity of thiazole derivatives as novel influenza neuraminidase inhibitors

A series of novel influenza neuraminidase (NA) inhibitors based on thiazole core were synthesized and evaluated for their ability to inhibit NA of influenza A virus (H3N2). All compounds were synthesized in good yields starting from commercially available 2-amino-4-thiazole-acetic ester using a suitable synthetic strategy. These compounds showed moderate inhibitory activity against influenza A NA. The most potent compound of this series is compound 4d (IC50=3.43 μM), which is about 20-fold less potent than oseltamivir, and could be used to design novel influenza NA inhibitors that exhibit increased activity based on thiazole ring.