1635-26-3Relevant academic research and scientific papers
EFFECT OF COPPER(II) IONS ON THE γ-RADIOLYSIS OF URACIL
Bhattacharyya, Sudhindra N.,Mandal, Parikshit C.
, p. 2613 - 2630 (2007/10/02)
Radiation sensitization of uracil (Ura) by CuII ions has been investigated using cobalt-60 γ-rays.In N2O-saturated solution, when no additive is present, the base degradation yield, G(-Ura), is only ca. 3.3, but when CuII ions are added in either a free or complexed state to the solution before irradiation, G(-Ura) is found to increase to ca. 5.1.The enhanced degradation of the base is derived from the oxidized transient, e.g.UraOH+, although reduction of CuII to CuI has been ascribed to all the primary adducts, e.g.UraH, UraOH and Ura-.Glycol and isobarbituric acid constitute the major products of radiolysis, which are derived from the oxidized UraOH+ species.Hydroxydihydrouracil and its dimer have also been detected in significant yields when the radiolysis is carried out at comparitively high absorbed doses.The formation of these products has been ascribed to a secondary reaction between UraOH and CuI which proceeds through the intermediate formation of a Cu-C bond.
Analysis of Radiolysis Products of Aqueous Uracil + N2O Solutions
Ali, Khondoker M. Idris,Scholes, George
, p. 449 - 456 (2007/10/02)
Various products from the irradiation of solutions of uracil+N2O with 60Co gamma rays were separated by paper chromatographic technique using 14C labelled materials.Identity of the isolated products was investigated by spectrophotometric and kinetic decomposition studies.Thus at least eight radiolytic products of uracil such as cis- and trans-uracil glycols, 5-hydroxy-6-hydro and 6-hydroxy-5-hydro compounds, isobarbituric acid and three dimeric products were identified.Yields of these products were determined at different pH values; a good material mass balance was achieved; the mechanism involved is discussed.
