16352-17-3

Basic information

• Product Name: 4,5-dimethyl-1,3,2-dioxaphospholane 2-oxide
• Synonyms: 1,3,2-dioxaphospholane, 4,5-dimethyl-, 2-oxide; 4,5-Dimethyl-1,3,2-dioxaphospholane 2-oxide
• CAS NO: 16352-17-3
• Molecular Formula: C₄H₉O₃P
• Molecular Weight: 136.0862
• Mol File: 16352-17-3.mol

Chemical Properties

• Boiling Point: 166.576°C at 760 mmHg
• Flash Point: 70.752°C
• Vapor Pressure: 2.336mmHg at 25°C
• CAS DataBase Reference: 4,5-dimethyl-1,3,2-dioxaphospholane 2-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: 4,5-dimethyl-1,3,2-dioxaphospholane 2-oxide(16352-17-3)
• EPA Substance Registry System: 4,5-dimethyl-1,3,2-dioxaphospholane 2-oxide(16352-17-3)

Safety Data

• Hazardous Substances Data: 16352-17-3(Hazardous Substances Data)

Upstream product

• 1758-32-3 2,3-epoxybutane 
• 15479-05-7 2-chloro-(4R*,5R*)-dimethyl-1,3,2-dioxaphospholane 
• 513-85-9 2.3-butanediol 
• 16352-28-6 2-chloro-4,5-dimethyl-1,3,2-dioxaphospholane 

Downstream Products

• 99786-12-6 α-p-Toluidino-benzylphosphonsaeure- 
• 109-89-7 diethylamine 
• 127936-42-9 4,5-dimethyl-2-(1-morpholino-1,2-diphenylethyl)-2-oxo-1,3,2-dioxaphospholane 
• 136001-48-4 4-[1-(4,5-Dimethyl-2-oxo-2λ⁵-[1,3,2]dioxaphospholan-2-yl)-1-p-tolyl-ethyl]-morpholine 
• 136001-49-5 4-[1-(4-Chloro-phenyl)-1-(4,5-dimethyl-2-oxo-2λ⁵-[1,3,2]dioxaphospholan-2-yl)-ethyl]-morpholine 
• 75841-77-9 4,5-dimethyl-2-phenyl(phenylamino)methyl-1,3,2λ⁵-benzodioxaphospholane 2-oxide 
• 136001-51-9 4-[1-(4,5-Dimethyl-2-oxo-2λ⁵-[1,3,2]dioxaphospholan-2-yl)-1-(4-nitro-phenyl)-ethyl]-morpholine 
• 136001-39-3 4-[1-(4,5-Dimethyl-2-oxo-2λ⁵-[1,3,2]dioxaphospholan-2-yl)-1-phenyl-ethyl]-morpholine 
• 127936-41-8 4,5-dimethyl-2-oxo-2-(1-piperidino-1-phenylethyl)-1,3,2-dioxaphospholane 

Relevant articles and documents

METHOD FOR THE SYNTHESIS OF HETEROCYCLIC HYDROGEN PHOSPHINE OXIDE

The present invention is related to a method for the synthesis of a heterocyclic hydrogen phosphine oxide, having the general formula (I), wherein: - R is a aliphatic or aromatic divalent group optionally comprising one or more heteroatoms and optionally comprising one or more substituents and - X and Y are independently selected from -O-, -C(O)O- and -NR'- wherein R' is a monovalent group optionally comprising one or more heteroatoms comprising the steps of: a) forming a reaction mixture by mixing a compound having the general formula HX-R-YH and tetraphosphorus hexaoxide; b) recovering the resulting compound comprising the heterocyclic hydrogen phosphine oxide.

New method of alkylene phosphonate preparation

A new method of alkylene phosphonate preparation has been elaborated, based on the reaction of the corresponding cyclic ethers and phosphonic acid in the presence of acetic anhydride.

Stereochemistry of organophosphorus cyclic compounds. Part 5. Synthesis and geometry of some 4,5-disubstituted 1,3,2-dioxaphospholan-2-thiones and stereochemistry of nucleophilic displacement reactions at phosphorus

Geometrical isomers of 2-hydroxy-4,5-dimethyl-1,3,2-dioxaphospholan-2-thione, 2-halogeno-4,5-dimethyl-1,3,2-dioxaphospholan-2-thione (X= Cl, Br, or F) and 2-hydroxy-4,5-diphenyl-1,3,2-dioxaphospholan-2-thione have been prepared in a stereospecific manner. Stereochemistries of these isomers are assigned on the basis of chemical correlations and n.m.r. measurements. 2-Chloro- and 2-bromo-4,5-dimethyl-1,3,2-dioxaphospholan-2-thione have been found to undergo methanolysis, aminolysis, and mercaptolysis with retention of configuration at phosphorus. Halogen-halogen exchange at the phosphorus atom is also described. The relationship between cis-and trans-geometry of disubstituted 1,3,2-dioxaphospholan-2-thiones and their 31P and 13C n.m.r. spectral parameters is briefly discussed.