163554-77-6

Upstream product

• 925-90-6 ethylmagnesium bromide 
• 114368-05-7 1-benzyl-2-pyrrolidinone-4-carboxylic acid chloride 
• 5733-86-8 1-benzyl-5-oxopyrrolidine-3-carboxylic acid 
• 1027599-40-1 2-(1-Benzyl-5-oxo-pyrrolidine-3-carbonyl)-2-methyl-malonic acid diethyl ester 

Downstream Products

• 107259-21-2 1-benzyl-4-(1-hydroxyiminopropyl)-2-pyrrolidone 
• 107259-25-6 1-benzyl-3-(1-tert-butoxycarbonylaminopropyl)pyrrolidine 
• 107259-20-1 4-(1-aminopropyl)-1-benzyl-2-pyrrolidone 
• 107259-24-5 3-(1-Aminopropyl)-1-benzylpyrrolidine 

Relevant academic research and scientific papers

An expedient approach for the synthesis of 1-Alkyl-4-propionylpyrrolidin-2- ones

A simple and useful tandem addition-cyclization reaction of primary amines on a prepared α-functionalized propylvinyl ketone 3 in methanol at reflux is a promising route for the synthesis of a new family of 1-alkyl-4- propionylpyrrolidin-2-ones 4. Taylor and Francis Group, LLC.

Reductive Alkylation of Tertiary Lactams via Addition of Organocopper (RCu) Reagents to Thioiminium Ions

A simple procedure for the conversion of tertiary lactams to 2-monoalkylated cyclic amines is described. The reaction sequence involves conversion of a lactam to a thioiminium ion followed by reaction with an organocopper (RCu) reagent and final reduction with triacetoxyborohydride. The reaction is high yielding and shows an excellent functional group tolerance. Its utility is demonstrated by a rapid synthesis of indolizidine 167B. The excellent chemoselectivity of the process, where only monoalkylation products are formed, is rationalized by a mechanism involving the formation of a transient enamine.

Synthesis and structure-activity relationships of 7-[3-(1- aminoalkyl)pyrrolidinyl]- and 7-[3-1-aminocycloalkyl)pyrrolidinyl]-quinolone antibacterials

A series of 7-[3-(1-aminoalkyl and 1-aminocycloalkyl)-1- pyrrolidinyl]quinolones have been prepared and their biological properties evaluated. Among them, 1-(S)-aminoalkyl derivatives exhibited potent antibacterial activities against gram-positive and gram-negative organisms. They had moderate lipophilicity and high aqueous solubility compared to their aminomethyl counterparts; e.g., the 3-(1-aminoethyl)-1-pyrrolidinyl compound (83) showed superior pharmacokinetic properties to its aminomethyl counterpart (6).