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5733-86-8

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5733-86-8 Usage

General Description

1-Benzyl-5-oxo-pyrrolidine-3-carboxylic acid is a chemical compound that belongs to the class of pyrrolidine carboxylic acids. It is a derivative of pyrrolidine and contains a benzyl group and a carboxylic acid group. 1-BENZYL-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID has potential applications in medicinal chemistry and drug development due to its ability to act as a building block for the synthesis of various bioactive molecules. It has been studied for its potential biological activities and may have therapeutic effects in the treatment of certain diseases. Further research and development of this compound may lead to the discovery of new pharmaceutical agents with diverse applications in the field of medicine and drug discovery.

Check Digit Verification of cas no

The CAS Registry Mumber 5733-86-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,7,3 and 3 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 5733-86:
(6*5)+(5*7)+(4*3)+(3*3)+(2*8)+(1*6)=108
108 % 10 = 8
So 5733-86-8 is a valid CAS Registry Number.
InChI:InChI=1S/C12H13NO3/c14-11-6-10(12(15)16)8-13(11)7-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H,15,16)

5733-86-8 Well-known Company Product Price

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  • TCI America

  • (B4264)  1-Benzyl-5-oxopyrrolidine-3-carboxylic Acid  >98.0%(GC)(T)

  • 5733-86-8

  • 1g

  • 1,790.00CNY

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5733-86-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-Benzyl-5-oxo-3-pyrrolidinecarboxylic Acid

1.2 Other means of identification

Product number -
Other names 1-benzyl-5-oxopyrrolidine-3-carboxylic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

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More Details:5733-86-8 SDS

5733-86-8Relevant articles and documents

Analgesic and anticancer activity of benzoxazole clubbed 2-pyrrolidinones as novel inhibitors of monoacylglycerol lipase

Afzal, Obaid,Altamimi, Abdulmalik Saleh Alfawaz,Hassan, Md Quamrul,Riadi, Yassine,Shahroz, Mir Mohammad,Sharma, Hemant Kumar

, (2021/05/28)

Ten benzoxazole clubbed 2-pyrrolidinones (11–20) as human monoacylglycerol lipase inhibitors were designed on the criteria fulfilling the structural requirements and on the basis of previously reported inhibitors. The designed, synthesized, and characterized compounds (11–20) were screened against monoacylglycerol lipase (MAGL) in order to find potential inhibitors. Compounds 19 (4-NO2 derivative) and 20 (4-SO2 NH2 derivative), with an IC50 value of 8.4 and 7.6 nM, were found most active, respectively. Both of them showed micromolar potency (IC50 value above 50 μM) against a close analogue, fatty acid amide hydrolase (FAAH), therefore considered as selective inhibitors of MAGL. Molecular docking studies of compounds 19 and 20 revealed that carbonyl of 2-pyrrolidinone moiety sited at the oxyanion hole of catalytic site of the enzyme stabilized with three hydrogen bonds (~2 ?) with Ala51, Met123, and Ser122, the amino acid residues responsible for the catalytic function of the enzyme. Remarkably, the physiochemical and pharmacokinetic properties of compounds 19 and 20, computed by QikProp, were found to be in the qualifying range as per the proposed guideline for good orally bioactive CNS drugs. In formalin-induced nociception test, compound 20 reduced the pain response in acute and late stages in a dose-dependent manner. They significantly demonstrated the reduction in pain response, having better potency than the positive control gabapentin (GBP), at 30 mg/kg dose. Compounds 19 and 20 were submitted to NCI, USA, for anticancer activity screening. Compounds 19 (NSC: 778839) and 20 (NSC: 778842) were found to have good anticancer activity on SNB-75 cell line of CNS cancer, exhibiting 35.49 and 31.88% growth inhibition (% GI), respectively.

Synthesis of a novel and potent small-molecule antagonist of PAC1 receptor for the treatment of neuropathic pain

Takasaki, Ichiro,Ogashi, Haruna,Okada, Takuya,Shimodaira, Ayaka,Hayakawa, Daichi,Watanabe, Ai,Miyata, Atsuro,Kurihara, Takashi,Gouda, Hiroaki,Toyooka, Naoki

, (2019/12/09)

We recently identified novel small-molecule antagonists of the PACAP type I (PAC1) receptor using docking-based in silico screening followed by in vitro/vivo pharmacological assays. In the present study, we synthesized 18 novel derivatives based on the structure of PA-9, a recently developed antagonist of the PAC1 receptor, with a view to obtain a panel of compounds with more potent antagonistic and analgesic activities. Among them, compound 3d showed improved antagonistic activities. Intrathecal injection of 3d inhibited both pituitary adenylate cyclase-activating polypeptide (PACAP) and spinal nerve ligation-induced mechanical allodynia. The effects were more potent than PA-9. Compound 3d also showed anti-allodynic effects following oral administration. Hence, our results suggest that 3d may become an orally available analgesic in the treatment of the neuropathic pain.

Site-Specific Synthesis of β-Fluorinated γ-Butyrolactams via Decarboxylative Fluorination of β-Carboxyl-γ-Butyrolactams

Phae-nok, Supasorn,Pohmakotr, Manat,Kuhakarn, Chutima,Reutrakul, Vichai,Soorukram, Darunee

, p. 4710 - 4720 (2019/08/01)

Monofluorinated cyclic nitrogen-containing compounds are synthetically useful scaffolds in organic synthesis and medicinal applications. In this report, AgNO3 mediated decarboxylative fluorination of β-carboxyl-γ-butyrolactams using Selectfluor as a fluorine source was described to achieve a site-specific synthesis of β-fluorinated γ-butyrolactams.

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