163555-56-4Relevant academic research and scientific papers
REACTIONS WITH 4,5-DI(p-CHLOROPHENYL)IMIDAZOLIDINE-2-THIONE
Sharaf, Mohie A. F.,Ezat, El-Emam H. M.,Hammouda, Hamdy A. A.
, p. 19 - 28 (2007/10/02)
Alkylation of 1 gave the S-alkyl derivatives 3a-c. The S-methyl derivative 3a reacted with amines, with the elimination of methanethiol, to give the 2-amino derivatives 4a-c; with thiosemicarbazide to yield the imidazos-triazole 6; and with anthranilic acids to yield the imidazoquinazolines 8a,b. Compound 3a reacted also with active-methylene compounds to give the ketene aminals 10a-c. Alkylation of 1 with dihaloalkanes afforded the bis compounds 14a,b. In the case of 1,2-dibromoethane, the imidazothiazole 13 was obtained. The reaction of 1 with α-halo-ketones led directly to the imidazothiazoles 15a-c and 17. However, with halo-acetoacetanilides, the acyclic intermediates 20d-g were isolated. Key words: Alkylation, ketene aminals, imidazo heterocycles.
