16357-68-9 Usage
Uses
Used in Pharmaceutical Synthesis:
5-Pyrimidinecarbonitrile, 4-chloro(8CI,9CI) is used as a key intermediate in the development of new drugs and biologically active molecules. Its unique structure allows for the creation of a variety of pharmaceutical compounds with diverse therapeutic applications.
Used in Agrochemical Production:
In the agrochemical industry, 5-Pyrimidinecarbonitrile, 4-chloro(8CI,9CI) serves as a crucial component in the synthesis of various agrochemicals, contributing to the development of effective pest control agents and other agricultural products.
Used in Organic Compounds Synthesis:
5-Pyrimidinecarbonitrile, 4-chloro(8CI,9CI) is utilized as a versatile building block in the synthesis of a range of organic compounds, expanding the scope of chemical research and innovation.
Used in Chemical Research and Drug Discovery:
5-Pyrimidinecarbonitrile, 4-chloro(8CI,9CI) plays a significant role in chemical research, providing a foundation for the exploration of new chemical reactions and the discovery of novel drug candidates with potential therapeutic benefits.
Check Digit Verification of cas no
The CAS Registry Mumber 16357-68-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,6,3,5 and 7 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 16357-68:
(7*1)+(6*6)+(5*3)+(4*5)+(3*7)+(2*6)+(1*8)=119
119 % 10 = 9
So 16357-68-9 is a valid CAS Registry Number.
16357-68-9Relevant academic research and scientific papers
Preparation method of medical intermediate 4-chloro-5-cyanopyrimidine
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Paragraph 0009; 0024-0025, (2021/11/03)
The invention discloses a preparation method of a medical intermediate 4-chloro-5-cyanopyrimidine. The method comprises the following steps: carrying out ring closing reaction on a compound 2-cyano-3-ethyoxyl ethyl acrylate as shown in a formula (II) and a compound formamidine acetate as shown in a formula (III) in a protonic solvent in the presence of sodium alcoholate to obtain a compound as shown in a formula (IV); and carrying out a chlorination reaction with any one or two or more than two of phosphorus pentachloride, phosphorus oxychloride, thionyl chloride or phosphorus trichloride to prepare the compound 4-chloro-5-cyanopyrimidine as shown in the formula (I). The preparation method disclosed by the invention has the following beneficial effects that the synthesis route is short, the synthesis is convenient, the yield is high, the toxicity of raw materials is small, the environmental pollution is relatively low, and the advantages of high purity, high yield, simple operation and industrialization are achieved; and the product obtained by adopting the method disclosed by the invention is convenient to purify, high in purification efficiency and good in effect. The method is suitable for manufacturers for preparing the medical intermediate 4-chloro-5-cyanopyrimidine.
