16357-83-8

Basic information

• Product Name: 5-Pyrimidinecarboxaldehyde, 4-amino- (8CI,9CI)
• Synonyms: 5-Pyrimidinecarboxaldehyde, 4-amino- (8CI,9CI);4-Aminopyrimidine-5-carbaldehyde;4-Aminopyrimidine-5-carboxaldehyde;4-Amino-5-formylpyrimidine;5-Pyrimidinecarboxaldehyde, 4-amino-
• CAS NO: 16357-83-8
• Molecular Formula: C₅H₅N₃O
• Molecular Weight: 123.1127
• Product Categories: PYRIMIDINE
• Mol File: 16357-83-8.mol
• Article Data: 7

Chemical Properties

• Melting Point: 192-200℃
• Boiling Point: 330 °C at 760 mmHg
• Flash Point: 153.4 °C
• Appearance: /
• Density: 1.37g/cm³
• Vapor Pressure: 0.000172mmHg at 25°C
• Refractive Index: 1.666
• Storage Temp.: 2-8°C
• Water Solubility: Slightly soluble in water.
• Sensitive: Air Sensitive
• CAS DataBase Reference: 5-Pyrimidinecarboxaldehyde, 4-amino- (8CI,9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Pyrimidinecarboxaldehyde, 4-amino- (8CI,9CI)(16357-83-8)
• EPA Substance Registry System: 5-Pyrimidinecarboxaldehyde, 4-amino- (8CI,9CI)(16357-83-8)

Safety Data

• Hazard Codes: Xn
• Statements: 22-43
• Safety Statements: 36/37
• WGK Germany: 3
• Hazardous Substances Data: 16357-83-8(Hazardous Substances Data)

Usage

General Description

5-Pyrimidinecarboxaldehyde, 4-amino- (8CI,9CI) is a chemical compound with the molecular formula C5H5N3O. It is a derivative of pyrimidine and contains an aldehyde functional group and an amino group. 5-Pyrimidinecarboxaldehyde, 4-amino- (8CI,9CI) is used in organic synthesis as a building block for the production of various pharmaceuticals and agrochemicals. It also has potential applications in the field of materials science, including the development of novel polymers and functional materials. The chemical properties and reactivity of 5-Pyrimidinecarboxaldehyde, 4-amino- (8CI,9CI) make it a versatile intermediate in the synthesis of diverse chemical compounds with wide-ranging industrial and research applications.

InChI:InChI=1/C5H5N3O/c6-5-4(2-9)1-7-3-8-5/h1-3H,(H2,6,7,8)

Upstream product

• 16357-69-0 4-amino-5-cyanopyrimidine 

Downstream Products

• 1386981-48-1 tert-butyl 3-(4-chloro-3-(7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzamido)-3-phenylpropylcarbamate 
• 1386981-47-0 4-Chloro-3-(7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzoic acid 
• 1386981-46-9 methyl 4-chloro-3-(7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzoate 
• 1386981-45-8 tert-butyl 2-(4-chloro-3-(7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzamido)-2-phenylethylcarbamate 
• 1011806-31-7 7-[2-(4-n-butylphenyl)-6-(1-ethoxyvinyl)pyrimidin-4-yl]pyrido[2,3-d]pyrimidine 
• 1011806-30-6 7-[2-(4-dodecyloxyphenyl)-6-(1-ethoxyvinyl)pyrimidin-4-yl]pyrido[2,3-d]pyrimidine 
• 442128-69-0 4,6-bis(2-amino-3-formylpyridyl)-2-(4-benzyloxyphenyl)pyrimidine 
• 442128-59-8 4,6-bis(2-amino-3-formylpyridyl)-2-(4-n-butylphenyl)pyrimidine 

Relevant articles and documents

INDOLE AHR INHIBITORS AND USES THEREOF

The present invention provides compounds useful as inhibitors of AHR, compositions thereof, and methods of using the same.

cGAS ANTAGONIST COMPOUNDS

Disclosed are novel compounds of Formula (I) that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.

Bicarbonate receptor compounds

The invention relates to a compound having the general formula I wherein A1 and A2 are selected from the group consisting of carbon (=CH-) and nitrogen (=N-); D1 and D2 are selected from the group consisting of-OH, -SH and -NHR1 groups, wherein R1 is hydrogen, hydrophilic substituent, hydrophobic substituent or linker; X1 and X2 are selected from the group consisting of oxygen (=O), sulphur (=S) and =NR2 group, wherein R2 is hydrogen, hydrophilic substituent, hydrophobic substituent or linker; X3 is selected from the group consisting of oxygen (=O), sulphur (=S), =NR2 group and two singly bonded moieties, wherein both moieties are hydrogen or one moiety is hydrogen and the other moiety is selected from the group of hydrophilic substituent, hydrophobic substituent and linker; and R1-R9 are selected from the group consisting of hydrogen, electron donating substituent, electron accepting substituent, hydrophilic substituent, hydrophobic substituent and linker, or R3 and R4 and/or R6 and R7 form together an aromatic or heteroaromatic, substituted or unsubstituted ring and the remaining moieties R1-R9 are as defined above.