16357-69-0 Usage
Description
4-Amino-5-pyrimidinecarbonitrile (APC) is a pyrimidine derivative synthesized through a three-component reaction involving benzaldehyde, benzamidine hydrochloride, and malononitrile. It is characterized by its white to brown solid appearance, and its chemical properties have been studied through various spectroscopic techniques, including infrared, 1H NMR, 13C NMR, and mass spectra.
Uses
Used in Pharmaceutical Industry:
4-Amino-5-pyrimidinecarbonitrile is used as a monodentate ligand for the preparation of metal complexes with Co(II), Ni(II), Cu(II), and Pd(II) ions. These metal complexes have potential applications in various pharmaceutical and therapeutic areas due to their unique chemical and biological properties.
Used in Chemical Synthesis:
APC serves as a reactant in the synthesis of 1H-pyrimido[4,5-d]pyrimidine-2,4-dione, which is an important intermediate compound in the development of various pharmaceuticals and chemical products. Its role as a reactant allows for the creation of new molecules with potential applications in different industries.
Check Digit Verification of cas no
The CAS Registry Mumber 16357-69-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,6,3,5 and 7 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 16357-69:
(7*1)+(6*6)+(5*3)+(4*5)+(3*7)+(2*6)+(1*9)=120
120 % 10 = 0
So 16357-69-0 is a valid CAS Registry Number.
InChI:InChI=1/C5H4N4/c6-1-4-2-8-3-9-5(4)7/h2-3H,(H2,7,8,9)
16357-69-0Relevant articles and documents
An improved preparation of 4-aminopyrimidine-5-carboxaldehyde
Bell, Thomas W.,Beckles, Daniel L.,Debetta, Michele,Glover, Brian R.,Hou, Zheng,Hung, Kar-Yan,Khasanov, Alisher B.
, p. 321 - 325 (2002)
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Heterocyclic compound used as MNK inhibitor
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Paragraph 0167, (2019/01/08)
The invention relates to a heterocyclic compound, a pharmaceutical composition containing the heterocyclic compound, a preparation method thereof, and application thereof used as a mitogen activated protein kinase interacting kinase 1 and 2-MNK1/MNK2 inhibitor. The inhibitor is the heterocyclic compound as shown in the formula (I), or its pharmaceutically acceptable salt, prodrug, solvent compound, polycrystal, isomer, stable isotope derivative or a pharmaceutical composition containing the heterocyclic compound. The compound of the invention can be used for treating or preventing MNK-mediatedrelated diseases, such as cancers.
PYRIDO PYRIMIDINES
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Page/Page column 79, (2012/07/28)
Compounds of formula and pharmaceutically acceptable salts thereof are described, as well as the pharmaceutical compositions containing said compounds and their pharmaceutically acceptable salts, and the use of said compounds and pharmaceutical compositions for the treatment, control or amelioration of proliferative diseases, including cancer, Down syndrome or early onset Alzheimer's disease.