163587-59-5Relevant articles and documents
Inhibition of human neutrophil elastase with peptidyl electrophilic ketones. 2. Orally active p(G)-Val-Pro-Val pentafluoroethyl ketones
Angelastro,Baugh,Bey,Burkhart,Chen,Durham,Hare,Huber,Janusz,Koehl,Marquart,Mehdi,Peet
, p. 4538 - 4553 (1994)
Valylprolylvalyl pentafluoroethyl ketones with different N-protecting groups were evaluated in vitro and in vivo as inhibitors of human neutrophil elastase (HNE). Several of these compounds were found to be orally active in HNE-induced rat and hamster lun