Inhibition of human neutrophil elastase with peptidyl electrophilic ketones. 2. Orally active p(G)-Val-Pro-Val pentafluoroethyl ketones

DOI: 10.1021/jm00052a013

Source and publish data:

Journal of Medicinal Chemistry p. 4538 - 4553 (1994)

Update date:2022-08-04

Topics: Orally Active Inhibition human neutrophil elastase

Authors:

Angelastro

Baugh Baugh

Bey Bey

Burkhart

Chen Chen

Durham Durham

Hare Hare

Huber Huber

Janusz Janusz

Koehl Koehl

Marquart

Mehdi Mehdi

Peet Peet

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Article abstract of DOI:10.1021/jm00052a013

Valylprolylvalyl pentafluoroethyl ketones with different N-protecting groups were evaluated in vitro and in vivo as inhibitors of human neutrophil elastase (HNE). Several of these compounds were found to be orally active in HNE-induced rat and hamster lun

Full text of DOI:10.1021/jm00052a013

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