163659-25-4

Upstream product

• 100-44-7 benzyl chloride 
• 69619-23-4 ethyl (S)-4-[(tert-butoxycarbonyl)amino]-3-oxopentanoate 
• 100-39-0 benzyl bromide 
• 69619-25-6 ethyl (3RS,4S)-4-(tert-butoxycarbonylamino)-3-hydroxypentanoate 
• 104700-37-0 ethyl [L-(trans)]-4-[(t-butoxycarbonyl)amino]-2-pentenoate 
• 54430-64-7 [(1S)-2-imidazol-1-yl-1-methyl-2-oxo-ethyl]-carbamic acid tert-butyl ester 
• 15761-38-3 L-N-Boc-Ala 
• 58632-95-4 2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile 
• 163659-23-2 4-(R)-(1-(S)-aminoethyl)-1-benzyl-2-pyrrolidone 

Downstream Products

• 163659-23-2 4-(R)-(1-(S)-aminoethyl)-1-benzyl-2-pyrrolidone 
• 146981-10-4 7-[(R)-3-((S)-1-Amino-ethyl)-pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid 
• 163659-24-3 1-benzyl-3-(R)-(1-(S)-tert-butoxycarbonylaminoethyl)pyrrolidine 

Relevant academic research and scientific papers

Antimicrobial quinolones, their compositions and uses

This invention relates to novel antimicrobial compounds of formula; wherein X, R1, R3, R5, R6, and R8 are defined in the claims, and to their optical isomers, diastereomers or enantiomers, as well as pharmaceutically-acceptable salts, hydrates, and biohydrolyzable esters, amides and imides thereof, and to compositions and uses of such compounds. The invention also relates to compounds derived from these compounds having antimicrobial uses.

Synthesis and structure-activity relationships of 7-[3-(1- aminoalkyl)pyrrolidinyl]- and 7-[3-1-aminocycloalkyl)pyrrolidinyl]-quinolone antibacterials

A series of 7-[3-(1-aminoalkyl and 1-aminocycloalkyl)-1- pyrrolidinyl]quinolones have been prepared and their biological properties evaluated. Among them, 1-(S)-aminoalkyl derivatives exhibited potent antibacterial activities against gram-positive and gram-negative organisms. They had moderate lipophilicity and high aqueous solubility compared to their aminomethyl counterparts; e.g., the 3-(1-aminoethyl)-1-pyrrolidinyl compound (83) showed superior pharmacokinetic properties to its aminomethyl counterpart (6).