16367-99-0Relevant academic research and scientific papers
Copper-Catalyzed C–C Bond Cleavage/Double Cyclization of α-Ketoamides with o-Phenylene Diamines: Synthesis of Benzimidazo[1,2-c]quinazolin-6-ones
Zou, Liang-Hua,Yan, Cheng,Shi, Kai,Su, Liang,Zhu, Shuai,Jia, Zhe-Kang,Wang, Qiuan
, p. 7725 - 7729 (2019)
A highly regioselective C–C bond cleavage/double cyclization of α-ketoamides with o-phenylene diamines has been developed for the synthesis of benzimidazo[1,2-c]quinazolin-6-ones. Two new C–N and one new C=N bonds are simultaneously formed in the reaction, providing the gateway to access these fused heterocyclic scaffolds via copper catalysis under air atmosphere. This new protocol provides a novel and important foundation for the preparation of these heterocycles.
Reaction of 1,2-Dihydronaphthoxazin-2,4(H)-dione with ortho-Substituted Anilines
Padmaja, J.,Reddy, M. Satyanarayana,Ratnam, C. V.
, p. 951 - 954 (2007/10/02)
A comparative study of the reactions of 1,2-dihydronaphthoxazin-2,4(H)-dione (1) and 2H-3,1-benzoxazin-2,4(H)-dione (8) (isatoic anhydride) with ortho-substituted anilines has been carried out.Condensation of these compounds with 1,2-diaminobenzenes yields the condensed imidazoles and imidazoquinazolinones, while with 2-aminophenol and 2-aminothiophenol condensed oxazoles and thiazoles respectively are formed.
