1638-75-1

Basic information

• Product Name: Chloromethyl(dimethyl)phosphine Oxide
• Synonyms: Phosphine oxide, (chloromethyl)dimethyl-; (Chloromethyl)dimethylphosphine oxide; (chloromethyl)(dimethyl)phosphane oxide
• CAS NO: 1638-75-1
• Molecular Formula: C₃H₈ClOP
• Molecular Weight: 126.5218
• EINECS: 216-675-1
• Mol File: 1638-75-1.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 257.8°C at 760 mmHg
• Flash Point: 109.7°C
• Density: 1.113g/cm³
• Vapor Pressure: 0.0229mmHg at 25°C
• Refractive Index: 1.402
• CAS DataBase Reference: Chloromethyl(dimethyl)phosphine Oxide(CAS DataBase Reference)
• NIST Chemistry Reference: Chloromethyl(dimethyl)phosphine Oxide(1638-75-1)
• EPA Substance Registry System: Chloromethyl(dimethyl)phosphine Oxide(1638-75-1)

Safety Data

• Hazardous Substances Data: 1638-75-1(Hazardous Substances Data)

Usage

General Description

Chloromethyl(dimethyl)phosphine oxide is a chemical compound with the formula (CH3)2P(O)CH2Cl. It is a highly reactive and flammable liquid that is used in organic synthesis and as a reagent in various chemical reactions. Chloromethyl(dimethyl)phosphine Oxide is commonly used as a precursor to produce phosphine oxides, which are important intermediates in the synthesis of various organic compounds. It is also utilized in the manufacturing of pharmaceuticals, pesticides, and other fine chemicals. However, chloromethyl(dimethyl)phosphine oxide is considered hazardous and should be handled with caution due to its flammability and potential toxic effects if not used properly.

Upstream product

• 26350-26-5 chloromethyl(methyl)phosphinic chloride 
• 676-58-4 methylmagnesium chloride 
• 7211-39-4 dimethyl phosphine oxide 
• 5850-00-0 (hydroxymethyl)-dimethylphosphine oxide 
• 55339-62-3 (chloromethyl)dimethylphosphane 
• 50636-62-9 dimethyl(acetoxymethyl)phosphine oxide 

Downstream Products

• 82154-47-0 pyrocatechol bis<(dimethylphosphinyl)methyl> ether 
• 97910-29-7 o-dimethylphosphinylmethoxyphenol 
• 111963-32-7 4-(Dimethyl-phosphinoylmethoxy)-3-methoxy-benzaldehyde 
• 139605-04-2 1,4-bis(dimethylphosphinylmethyleneoxy)benzene 
• 92465-81-1 1-(Dimethyl-phosphinoylmethoxy)-4-nitro-benzene 
• 139605-05-3 1,3,5-tris(dimethylphosphinylmethyleneoxy)benzene 
• 139605-02-0 1-dimethylphosphinylmethylenoxy-4-methyl-2,6-bis(1,1-dimethylethyl)benzene 
• 139605-08-6 2,2'-methylene-bis(6-tert-butyl-4-ethyl-1-dimethylphosphinylmethylenoxybenzene) 
• 111963-35-0 2-Chloro-1-(dimethyl-phosphinoylmethoxy)-4-nitro-benzene 
• 139605-07-5 2,2-methylene-bis(6-tert-butyl-4-methyl-1-dimethylphosphinylmethyleneoxybenzene) 
• 139613-06-2 1,1,3-tris(5'-tert-butyl-2'-methyl-4'-dimethylphosphinylmethyleneoxybenzene)butane 
• 53236-13-8 dimethyl(phenoxymethyl)phosphine oxide 
• 53236-15-0 1-Bromo-4-(dimethyl-phosphinoylmethoxy)-benzene 
• 61148-97-8 dimethylphosphinyl-methyl N-(3-trifluoromethylphenyl)-anthranilate 

Relevant articles and documents

Phosphinylmethylphosphinates as chelating ligands

(Dimethylphosphinyl)-, (methylphenylphosphinyl)-, and (diphenylphosphinyl)methylphenylphosphinic acids have been prepared by hydrolysis of the Michaelis-Arbuzov reaction products of the appropriate chloromethylphosphine oxides and diethyl phenylphosphonite. They react with Zn(C2H3O2)2·2H2O and Cr(C5H7O2)3 under suitable conditions to yield the corresponding bis and tris chelates, except for the diphenyl-chromium(III) derivative, which was prepared in low yield via the chromium(II) derivative. The zinc derivatives are dimers, the chromium derivatives monomers. The metal chelates are more thermally stable than the corresponding acetylacetonates. Their infrared and 1H n.m.r. spectra are discussed.

The effect of the phosphoryl group on the rate and mechanism of SN-substitution at the saturated carbon atoms

The reactivity of diarylphosphine oxides RR'P(O)CH2X with p-O2NC6H4ONa in DMF have been studied.The reaction rate increases with the electrodrawing properties of the substituents on R and R' in the following way: p-Me2NC6H4 2 reaction rate of diphenylphosphine oxides has been investigated.The reactivity increases as follows Cl I Br OTs.A reaction mechanism is suggested.

SYNTHESIS OF CHLOROMETHYLPHOSPHINE OXIDES

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