1638-75-1

Usage

Uses

Used in Organic Synthesis:
Chloromethyl(dimethyl)phosphine Oxide is used as a reagent in organic synthesis for its ability to facilitate the formation of complex organic molecules. Its reactivity allows it to participate in a variety of chemical reactions, making it a versatile component in the creation of new compounds.
Used in Pharmaceutical Manufacturing:
In the pharmaceutical industry, Chloromethyl(dimethyl)phosphine Oxide is used as a precursor to produce phosphine oxides, which are key intermediates in the synthesis of various pharmaceuticals. Its role in creating these intermediates is essential for the development of new drugs and medicines.
Used in Pesticide Production:
Chloromethyl(dimethyl)phosphine Oxide is also utilized in the manufacturing of pesticides. Its reactivity and ability to form phosphine oxides contribute to the creation of effective compounds that protect crops and control pests.
Used in the Production of Fine Chemicals:
Chloromethyl(dimethyl)phosphine Oxide is employed in the production of fine chemicals, where its reactivity and capacity to form phosphine oxides are harnessed to create specialty chemicals used in various applications, including fragrances, dyes, and other industrial chemicals.
Safety Considerations:
Due to its flammability and potential toxic effects if not handled properly, Chloromethyl(dimethyl)phosphine Oxide is considered hazardous. It requires careful handling and storage to prevent accidents and ensure the safety of those working with it in research and industrial settings.

Upstream product

• 50636-62-9 dimethyl(acetoxymethyl)phosphine oxide 
• 7211-39-4 dimethyl phosphine oxide 
• 26350-26-5 chloromethyl(methyl)phosphinic chloride 
• 676-58-4 methylmagnesium chloride 
• 55339-62-3 (chloromethyl)dimethylphosphane 
• 5850-00-0 (hydroxymethyl)-dimethylphosphine oxide 

Downstream Products

• 82154-47-0 pyrocatechol bis<(dimethylphosphinyl)methyl> ether 
• 97910-29-7 o-dimethylphosphinylmethoxyphenol 
• 61149-27-7 dimethylphosphinylmethyl N-(8-trifluoromethyl-4-quinoyl)-anthranilate 
• 111963-31-6 3-(Dimethyl-phosphinoylmethoxy)-benzaldehyde 
• 1441771-11-4 dimethyl 5-((dimethylphosphoryl)methoxy)-isophthalate 
• 1394345-92-6 3-[1-(2,6-dichloro-3-fluoro-phenyl)ethoxy]-5-[1-[1-(dimethylphosphorylmethyl)-4-piperidyl]pyrazol-4-yl]pyridin-2-amine 
• 1021879-79-7 α-(dimethylphosphoryl)methyl 5-(1-phenyl)-1H-tetrazolyl sulfide 
• 69840-28-4 3-benzhydryl-3H-imidazole-4-carboxylic acid dimethylphosphinoylmethyl ester 

Relevant academic research and scientific papers

Phosphinylmethylphosphinates as chelating ligands

(Dimethylphosphinyl)-, (methylphenylphosphinyl)-, and (diphenylphosphinyl)methylphenylphosphinic acids have been prepared by hydrolysis of the Michaelis-Arbuzov reaction products of the appropriate chloromethylphosphine oxides and diethyl phenylphosphonite. They react with Zn(C2H3O2)2·2H2O and Cr(C5H7O2)3 under suitable conditions to yield the corresponding bis and tris chelates, except for the diphenyl-chromium(III) derivative, which was prepared in low yield via the chromium(II) derivative. The zinc derivatives are dimers, the chromium derivatives monomers. The metal chelates are more thermally stable than the corresponding acetylacetonates. Their infrared and 1H n.m.r. spectra are discussed.

NOVEL GLUCOKINASE ACTIVATORS AND METHODS OF USING SAME

Compounds are provided which are phosphonate and phosphinate activators and thus are useful in treating diabetes and related diseases and have the structure wherein is a heteroaryl ring; R4 is —(CH2)n-Z-(CH2)m—PO(OR7)(OR8), —(CH2)nZ-(CH2)m—PO(OR7)Rg, —(CH2)n-Z-(CH2)m—OPO(OR7)Rg, —(CH2)nZ—(CH2)m—OPO(R9)(R10), or —(CH2)nZ—(CH2)m—PO(R9)(R10);R5 and R6 are independently selected from H, alkyl and halogen;Y is R7(CH2)s or is absent; andX, n, Z, m, R4, R5, R6, R7, and s are as defined herein; or a pharmaceutically acceptable salt thereof. A method for treating diabetes and related diseases employing the above compounds is also provided.

The effect of the phosphoryl group on the rate and mechanism of SN-substitution at the saturated carbon atoms

The reactivity of diarylphosphine oxides RR'P(O)CH2X with p-O2NC6H4ONa in DMF have been studied.The reaction rate increases with the electrodrawing properties of the substituents on R and R' in the following way: p-Me2NC6H4 2 reaction rate of diphenylphosphine oxides has been investigated.The reactivity increases as follows Cl I Br OTs.A reaction mechanism is suggested.

Functional Derivatives of Trimethylphosphane, XV. (Chloromethyl)dimethylphosphane

(Chloromethyl)dimethylphosphane, Me2P(CH2Cl) (3), which is unstable at room temperature, has been synthesized.Reactions with O2, CH3Br and LiPMe2 give Me2P(O)(CH2Cl) (4), Br (5b) and Me2PCH2PMe2 (2), respectively.NMR data for these and related compounds are given.

Production of halogen-containing tertiary phosphine oxides

Production of halogen-containing tertiary phosphine oxides of the general formula (I) STR1 in which R1 stands for an alkyl, halogenoalkyl, alkenyl, halogenoalkenyl, alkinyl or halogenoalkinyl radical, each of these radicals containing from 1 to 18 carbon atoms, or stands for a cycloalkyl, a halogenated cycloalkyl, an aryl, a halogenated aryl, an aralkyl or a halogenated aralkyl radical, and X stands for halogen. The oxides are made by subjecting a compound of the general formula (II) STR2 in which R has the same meaning as R1 and X stands for halogen, to thermal treatment in the presence of hydrogen halide at atmospheric or at elevated pressure so as to split off water and formaldehyde in vapor form therefrom; by continuously freeing the resulting reaction mixture from the said components in vapor form; by terminating the reaction and thereafter stripping off the hydrogen halide from the reaction mixture by introducing an inert gas thereinto; and by purifying the remaining crude product by distillation or recrystallization.