16382-24-4

Basic information

• Product Name: 1H-Indole, 5-(phenylmethoxy)-1-(phenylmethyl)-
• CAS NO: 16382-24-4
• Molecular Formula: C22H19NO
• Molecular Weight: 313.399
• Mol File: 16382-24-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1H-Indole, 5-(phenylmethoxy)-1-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole, 5-(phenylmethoxy)-1-(phenylmethyl)-(16382-24-4)
• EPA Substance Registry System: 1H-Indole, 5-(phenylmethoxy)-1-(phenylmethyl)-(16382-24-4)

Safety Data

• Hazardous Substances Data: 16382-24-4(Hazardous Substances Data)

Usage

Compound type

chemical compound

Indole derivative

Yes

Heterocyclic aromatic compound

Yes

Phenylmethoxy substituent

Present

Phenylmethyl substituent

Present

Potential biological activities

Possible

Research interest

Medicinal chemistry and pharmacology

Further studies needed

Yes

Potential applications

Unknown, requires further research

Upstream product

• 1215-59-4 5-benzyloxy-1H-indole 
• 100-39-0 benzyl bromide 

Downstream Products

• 142769-36-6 1-benzyl-1H-indol-5-ol 
• 1215-59-4 5-benzyloxy-1H-indole 
• 161460-39-5 4-[(1-benzyl-1H-indol-5-yl)oxy]-3-chlorobenzonitrile 
• 161459-96-7 YM-32906 
• 374818-30-1 3-(N-benzyl-5-benzyloxyindol-3-yl)-1H-pyrrole-2,5-dione 
• 1274877-72-3 1-benzyl-5-(benzyloxy)-1H-indol-3-yl acetate 
• 1312440-09-7 1,3,7-trimethyl-8-(1-benzyl-5-(benzyloxy)-1H-indol-3-yl)xanthine 
• 1423160-24-0 3-ethoxycarbonyl-3-(1-benzyl-5-benzyloxyindol-3-yl)isoindolin-1-one 

Relevant articles and documents

Pd-catalyzed direct and selective C-H functionalization: C3-acetoxylation of indoles

Direct functionalization of C-H bonds has been a hot topic in organic chemistry during recent years. Arenes-one of the most abundant chemical motifs-usually have multiple C-H bonds. Although, some examples of direct functionalizations of arenes have been

A novel class of inhibitors for human steroid 5α-reductase: Synthesis and biological evaluation of indole derivatives. II

In a search for novel nonsteroidal inhibitors of human prostatic 5α- reductase, we found a new series of indole derivatives that showed potent inhibitory activities for the human enzyme. Among them, 4-[(1-benzyl-1- Hindol-5-yl)oxy]-3-chlorobenzoic acid (2d, YM-32906) showed more potent inhibitory activity than finasteride with an IC50 value of 0.44 nM. 3- Chloro-4-{[1-(4-phenoxybenzyl)-1H-indol-5-yl]oxy}benzoic acid (2m) showed inhibitory activities for both human and rat prostatic 5α-reductase with IC50 values of 2.1 and 73 nM, respectively. The synthesis and structure- activity relationships of these indole derivatives are presented.