1638253-88-9Relevant articles and documents
Peculiarities of the cascade cleavage of the polarized C - C-fragment in α-ketoacetylenes on reaction with ethylene diamine
Vasilevsky, Sergei F.,Davydova, Maria P.,Tomilin, Denis N.,Sobenina, Lyubov N.,Mamatuyk, Victor I.,Pleshkova, Nadezhda V.
, p. 132 - 144 (2014/08/18)
The reaction of diarylketoacetylenes with ethylenediamine (EDA) leads to arylmethylketones and 2-substituted imidazoline derivatives. This transformation involves complete cleavage of the triple bond via initial intermolecular Michael-addition with subsequent intramolecular Michaeladdition. Final fragmentation can be presented as a retro-Mannich reaction, accompanied by three formal reductive stages (formation of three C-H bonds), while the other carbon undergoes a formal oxidation, in which three C-N bonds (C-N and C=N) are formed. ARKAT-USA, Inc.