1638287-55-4

Basic information

• Product Name: 4-NO₂-NFSI
• Synonyms: 4-NO₂-NFSI
• CAS NO: 1638287-55-4
• Molecular Weight: 360.344
• Mol File: 1638287-55-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-NO₂-NFSI(CAS DataBase Reference)
• NIST Chemistry Reference: 4-NO₂-NFSI(1638287-55-4)
• EPA Substance Registry System: 4-NO₂-NFSI(1638287-55-4)

Safety Data

• Hazardous Substances Data: 1638287-55-4(Hazardous Substances Data)

Upstream product

• 145490-75-1 N-fluorobenzene sulfonamide 
• 98-74-8 4-Nitrobenzenesulfonyl chloride 

Downstream Products

• 127-63-9 diphenyl sulphone 

Relevant articles and documents

Enantioselective fluorination of 2-oxindoles by structure-micro-tuned n-fluorobenzenesulfonamides

We describe our attempts to fine-tune the reactivity and selectivity of N-fluorobenzenesulfonamide in fluorination reactions by changing the substituents on its phenyl rings. A series of N-fluorobenzenesulfonamides bearing substituents at the ortho, meta, and para positions were prepared, and were used in the enantioselective fluorination of 2-oxindoles catalysed by chiral palladium complexes. Fluorinating reagents 1b, 1c, 1d, 1e, 1h, 1i, and 1j gave similar results to 1a, while 1f, 1g, and 1n gave worse yields and selectivities. Under mild reaction conditions, a series of 3-fluoro-2-oxindoles were obtained in excellent yields (up to 98%) and enantioselectivities (up to 99% ee) using N-fluoro-4,4′-difluoro-benzenesulfonamide as the fluorination agent. Copyright