16384-64-8Relevant academic research and scientific papers
Ligand-free Pd-catalyzed highly selective arylation of allylic esters with retention of the traditional leaving group
Pan, Delin,Chen, Anjun,Su, Yijin,Zhou, Wang,Li, Si,Jia, Wei,Xiao, Juan,Liu, Qingjian,Zhang, Liangren,Jiao, Ning
supporting information; experimental part, p. 4729 - 4732 (2009/02/06)
(Chemical Equation Presented) What leaving group? Organic halides and allylic esters undergo efficient Pd-catalyzed Heck reactions under mild conditions in air to form a new C-C bond without elimination of the β-OAc group in the intermediate palladium complex. Instead a highly regioselective β-H elimination takes place to provide substituted derivatives of allylic alcohols (see scheme).
