1638684-69-1Relevant articles and documents
Catalytic Asymmetric Synthesis of Chiral Spiro-cyclopropyl Oxindoles from 3-Alkenyl-oxindoles and Sulfoxonium Ylides
Wang, Lifeng,Cao, Weidi,Mei, Hongjiang,Hu, Linfeng,Feng, Xiaoming
supporting information, p. 4089 - 4093 (2018/10/02)
A new enantioselective cyclopropanation of 3-alkenyl-oxindoles with sulfoxonium ylides was realized by using a chiral N,N′-dioxide/Mg(OTf)2 complex as the catalyst. Various chiral spiro-cyclopropyl oxindoles containing two or three continuous chiral carbon centres were obtained in high yields (up to 99%) with good dr (up to 97:3 dr) and high ee values (up to 94% ee). (Figure presented.).
Asymmetric diastereoselective synthesis of spirocyclopropane derivatives of oxindole
Oseka, Maksim,Noole, Artur,Zari, Sergei,Oeeren, Mario,Jaerving, Ivar,Lopp, Margus,Kanger, Tonis
, p. 3599 - 3606 (2014/06/23)
A new asymmetric organocatalytic synthesis of spirocyclopropane oxindoles has been developed. The method is based on the Michael addition of N-Boc-protected 3-chlorooxindole to unsaturated 1,4-dicarbonyl compounds, affording trans-substituted spirocyclopropane oxindole derivatives in high diastereo- and enantioselectivity. Copyright