1638684-75-9Relevant academic research and scientific papers
Asymmetric diastereoselective synthesis of spirocyclopropane derivatives of oxindole
Oseka, Maksim,Noole, Artur,Zari, Sergei,Oeeren, Mario,Jaerving, Ivar,Lopp, Margus,Kanger, Tonis
, p. 3599 - 3606 (2014/06/23)
A new asymmetric organocatalytic synthesis of spirocyclopropane oxindoles has been developed. The method is based on the Michael addition of N-Boc-protected 3-chlorooxindole to unsaturated 1,4-dicarbonyl compounds, affording trans-substituted spirocyclopropane oxindole derivatives in high diastereo- and enantioselectivity. Copyright
