1639-37-8Relevant academic research and scientific papers
α-Alkoxycarbonyl-α-hydroxy secondary amides from a carbamoylsilane and α-ketoesters
Li, Weidong,Han, Yuling,Chen, Jianxin
, p. 5813 - 5819 (2017/09/05)
The addition of N-methoxymethyl-N-organylcarbamoyl(trimethyl)silane to α-ketoesters in anhydrous toluene at 60 °C afforded α-alkoxycarbonyl-α-siloxy amides in high yields (75–96%). The methoxymethyl was used as an amino protecting group and could be easily converted into hydrogen atom by simple acid hydrolysis leading to α-alkoxycarbonyl-α- hydroxy secondary amides.
A heterocyclic derivative of the industrial preparation method (by machine translation)
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Paragraph 0057-0059, (2017/04/27)
The present invention provides a heterocyclic derivative of the industrial preparation method, characterized in that compound B with diethyl oxalate ester instead should produce the target compound C, said compound B of the structure is shown as follows: the target compound C of the structure is shown as follows: the production method is simple, is different from the existing technology in the complex mode of production, the harsh conditions of production, the invention one-step synthesis of the target product can be realized. And because this invention to the production process and the synthetic route is optimized, in in the production process of the present invention, little side reaction, after treatment is convenient, the production condition is moderate, and is suitable for industrial production mode. (by machine translation)
Novel Synthesis of α-Keto Esters and Amides by an sp3 C-H Oxidation of Nitromethyl Aryl Ketones Promoted by Ion-Supported (Diacetoxyiodo)benzene
Jiang, Xiaoying,Gan, Bing,Liu, Jiwei,Xie, Yuanyuan
supporting information, p. 2737 - 2741 (2016/11/25)
A simple and efficient method is described for the preparation of α-keto esters or amides from nitromethyl aryl ketones. In the presence of nucleophiles (alcohols or amines), the ion-supported (di-acetoxyiodo)benzene-promoted sp3 C-H oxidation of nitromethyl aryl ketones proceeded efficiently under mild conditions to give the corresponding α-keto esters and amides in moderate to good yields. This is the first reported use of (diacetoxyiodo)benzene in the synthesis of α-keto esters and amides. The reaction is ecofriendly and has the -advantages of mild conditions, short reaction times, and a recyclable reagent.
Substituted azepine derivatives as serotonin receptor modulators
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Page/Page column 14; 33, (2010/02/15)
The present invention generally relates to a series of compounds, to pharmaceutical compositions containing the compounds, and to use of the compounds and compositions as therapeutic agents. More specifically, compounds of the present invention are hexahydroazepinoindole and octahydroazepinoindole compounds. These compounds are serotonin receptor (5-HT) ligands and are useful for treating diseases, disorders, and conditions wherein modulation of the activity of serotonin receptors (5-HT) is desired (e.g. anxiety, depression and obesity).
Enantioselective synthesis of both enantiomers of 2-amino-2-(2-furyl)ethan-1-ol as a flexible building block for the preparation of serine and azasugars
Demir, Ayhan S.,Sesenoglu, Oezge,Aksoy-Cam, Hilal,Kaya, Handan,Aydogan, Kenan
, p. 1335 - 1340 (2007/10/03)
The selective conversion of 1-(2-furyl)-2-hydroxyethan-1-one and ethyl 2-(2-furyl)-2-oxo acetate into (E)- and (Z)-oximes and oxime ethers followed by oxazaborolidine-catalyzed enantioselective reduction using different amino alcohols furnished both enantiomers of the important chiral building block 2-amino-2-(2-furyl)ethan-1-ol with an ee of up to 96%.
A new one step synthesis of maleimides by condensation of glyoxylate esters with acetamides
Faul, Margaret M.,Winneroski, Leonard L.,Krumrich, Christine A.
, p. 1109 - 1112 (2007/10/03)
Bisphenyl, bisheteroaryl, indolylaryl and indolylcycloalkyl maleimides are prepared in one step and 67-99% yield by condensation of glyoxylate esters with acetamides using a 1.0 M solution of potassium tert-butoxide in THF. The mechanism of the reaction is discussed.
